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352 results

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Page 1
APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
Chen L, Li N, Zhang M, Sun M, Bian J, Yang B, Li Z, Wang J, Li F, Shi X, Wang Y, Yuan F, Zou P, Shan C, Wang J. Chen L, et al. Angew Chem Int Ed Engl. 2021 Nov 22;60(48):25346-25355. doi: 10.1002/anie.202108961. Epub 2021 Oct 27. Angew Chem Int Ed Engl. 2021. PMID: 34550632
Here, by combining APEX2-based proximity labeling focused on the copper chaperone Atox1 with mass spectrometry we identified a previously unrecognized nuclear copper binding protein, Cysteine-rich protein 2 (CRIP2), that interacts with Atox1 in the nucleus. We show …
Here, by combining APEX2-based proximity labeling focused on the copper chaperone Atox1 with mass spectrometry we identified a previo …
ATOX1: a novel copper-responsive transcription factor in mammals?
Muller PA, Klomp LW. Muller PA, et al. Int J Biochem Cell Biol. 2009 Jun;41(6):1233-6. doi: 10.1016/j.biocel.2008.08.001. Epub 2008 Aug 7. Int J Biochem Cell Biol. 2009. PMID: 18761103 Review.
Recently, a novel function for Atox1 as a transcription factor (TF) regulating Ccnd1 was proposed. Crystal structures of ATOX1 reveal copper-dependent homodimerization of ATOX1. As many TFs regulate gene expression as a dimer and bind to DNA repeats, we inves …
Recently, a novel function for Atox1 as a transcription factor (TF) regulating Ccnd1 was proposed. Crystal structures of ATOX1 …
Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy.
Zhao P, Shi W, Ye Y, Xu K, Hu J, Chao H, Tao Z, Xu L, Gu W, Zhang L, Wang T, Wang X, Ji J. Zhao P, et al. Redox Biol. 2024 Jun;72:103156. doi: 10.1016/j.redox.2024.103156. Epub 2024 Apr 12. Redox Biol. 2024. PMID: 38640584 Free PMC article.
However, it remains unknown whether Atox1 is involved in modulating oxidative stress following TBI. Here, we investigated the regulatory role of Atox1 in oxidative stress on neurons both in vivo and in vitro, and elucidated the underlying mechanism through culturing …
However, it remains unknown whether Atox1 is involved in modulating oxidative stress following TBI. Here, we investigated the regulat …
Thiol-based copper handling by the copper chaperone Atox1.
Hatori Y, Inouye S, Akagi R. Hatori Y, et al. IUBMB Life. 2017 Apr;69(4):246-254. doi: 10.1002/iub.1620. Epub 2017 Mar 15. IUBMB Life. 2017. PMID: 28294521 Free article. Review.
Human antioxidant protein 1 (Atox1) plays a crucial role in cellular copper homeostasis. Atox1 captures cytosolic copper for subsequent transfer to copper pumps in trans Golgi network, thereby facilitating copper supply to various copper-dependent oxidereductases ma …
Human antioxidant protein 1 (Atox1) plays a crucial role in cellular copper homeostasis. Atox1 captures cytosolic copper for s …
The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution.
Hatori Y, Lutsenko S. Hatori Y, et al. Antioxidants (Basel). 2016 Jul 27;5(3):25. doi: 10.3390/antiox5030025. Antioxidants (Basel). 2016. PMID: 27472369 Free PMC article. Review.
Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway. ...
Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions …
Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway.
Chen M, Chen Y, Fu R, Liu S, Li H, Shen T. Chen M, et al. J Transl Med. 2024 May 25;22(1):497. doi: 10.1186/s12967-024-05314-4. J Transl Med. 2024. PMID: 38796413 Free PMC article.
These changes were alleviated in mice with Atox1 knockout. The effects of Atox1 on macrophage polarization were mediated via the ROS-NLRP3 inflammasome pathway. ...Atox1 is a potential therapeutic target in IBD....
These changes were alleviated in mice with Atox1 knockout. The effects of Atox1 on macrophage polarization were mediated via t …
The molecular mechanisms of copper metabolism and its roles in human diseases.
Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C. Chen J, et al. Pflugers Arch. 2020 Oct;472(10):1415-1429. doi: 10.1007/s00424-020-02412-2. Epub 2020 Jun 7. Pflugers Arch. 2020. PMID: 32506322 Review.
Then, Cu(+) can be secreted into the bile or the blood via the Atox1/ATP7B/ceruloplasmin route. In the bloodstream, this micronutrient can reach peripheral tissues and is again incorporated by Ctr1. In peripheral tissue cells, cuprous ions are either sequestrated by molecu …
Then, Cu(+) can be secreted into the bile or the blood via the Atox1/ATP7B/ceruloplasmin route. In the bloodstream, this micronutrien …
An expanding range of functions for the copper chaperone/antioxidant protein Atox1.
Hatori Y, Lutsenko S. Hatori Y, et al. Antioxid Redox Signal. 2013 Sep 20;19(9):945-57. doi: 10.1089/ars.2012.5086. Epub 2013 Feb 6. Antioxid Redox Signal. 2013. PMID: 23249252 Free PMC article. Review.
In vitro, Atox1 binds and transfers copper to the copper-transporting ATPases, stimulating their catalytic activity. Inactivation of Atox1 in cells inhibits maturation of secreted cuproenzymes as well as copper export from cells. ...
In vitro, Atox1 binds and transfers copper to the copper-transporting ATPases, stimulating their catalytic activity. Inactivation of …
Copper metabolism in cell death and autophagy.
Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X. Xue Q, et al. Autophagy. 2023 Aug;19(8):2175-2195. doi: 10.1080/15548627.2023.2200554. Epub 2023 Apr 16. Autophagy. 2023. PMID: 37055935 Free PMC article. Review.
This knowledge may help in the design of future clinical tools to improve cancer diagnosis and treatment.Abbreviations: ACSL4, acyl-CoA synthetase long chain family member 4; AIFM1/AIF, apoptosis inducing factor mitochondria associated 1; AIFM2, apoptosis inducing factor mitochon …
This knowledge may help in the design of future clinical tools to improve cancer diagnosis and treatment.Abbreviations: ACSL4, acyl-CoA synt …
Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer.
Jana A, Das A, Krett NL, Guzman G, Thomas A, Mancinelli G, Bauer J, Ushio-Fukai M, Fukai T, Jung B. Jana A, et al. PLoS One. 2020 Jan 21;15(1):e0227916. doi: 10.1371/journal.pone.0227916. eCollection 2020. PLoS One. 2020. PMID: 31961892 Free PMC article.
However, the role of Atox1 in metastasis has not been examined. METHODS: Atox1 expression was determined by immunofluorescence in a tissue microarray generated from a spectrum of CRC patients. ...Further, inhibition of endogenous Atox1 by siRNA in SW620 decre …
However, the role of Atox1 in metastasis has not been examined. METHODS: Atox1 expression was determined by immunofluorescence …
352 results