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Year | Number of Results |
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2018 | 2 |
2019 | 2 |
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Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain.
Cell Rep Med. 2023 Nov 21;4(11):101265. doi: 10.1016/j.xcrm.2023.101265. Epub 2023 Nov 8.
Cell Rep Med. 2023.
PMID: 37944527
Free PMC article.
We identify that hyperalgesic priming in mice increases the expression of a mitochondrial protein (ATPSc-KMT) and causes mitochondrial and metabolic disturbances in sensory neurons. Inhibition of mitochondrial respiration, knockdown of ATPSCKMT expression, or supplementati …
We identify that hyperalgesic priming in mice increases the expression of a mitochondrial protein (ATPSc-KMT) and causes mitochondrial and m …
Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.
Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Kjønstad IF, Burgering BMT, Zwartkruis F, Eijkelkamp N, Falnes PØ.
Małecki JM, et al.
J Biol Chem. 2019 Jan 25;294(4):1128-1141. doi: 10.1074/jbc.RA118.005473. Epub 2018 Dec 10.
J Biol Chem. 2019.
PMID: 30530489
Free PMC article.
In summary, we have identified FAM173B as the long-sought KMT responsible for methylation of ATPSc, a key protein in cellular ATP production, and have demonstrated functional significance of ATPSc methylation. We suggest renaming FAM173B to ATPSc-KMT (gene name ATPSCKMT).. …
In summary, we have identified FAM173B as the long-sought KMT responsible for methylation of ATPSc, a key protein in cellular ATP production …
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Identification of FAM173B as a protein methyltransferase promoting chronic pain.
Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Gonzalez Cano R, Zhou W, Jakobsson ME, Małecki J, Posthuma G, Habib AM, Heijnen CJ, Falnes PØ, Eijkelkamp N.
Willemen HLDM, et al.
PLoS Biol. 2018 Feb 14;16(2):e2003452. doi: 10.1371/journal.pbio.2003452. eCollection 2018 Feb.
PLoS Biol. 2018.
PMID: 29444090
Free PMC article.
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Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis.
Palada V, Siddiqah Ahmed A, Hugo A, Radojčić MR, Svensson CI, Kosek E.
Palada V, et al.
Rheumatology (Oxford). 2021 Apr 6;60(4):1724-1733. doi: 10.1093/rheumatology/keaa565.
Rheumatology (Oxford). 2021.
PMID: 33067627
Free PMC article.
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Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.
Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ.
Małecki JM, et al.
J Biol Chem. 2019 Aug 2;294(31):11654-11664. doi: 10.1074/jbc.RA119.009045. Epub 2019 Jun 18.
J Biol Chem. 2019.
PMID: 31213526
Free PMC article.
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