Atsumi R - Search Results

1

Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase.

Satoh T, Hosokawa M, Atsumi R, Suzuki W, Hakusui H, Nagai E. Satoh T, et al. Among authors: atsumi r. Biol Pharm Bull. 1994 May;17(5):662-4. doi: 10.1248/bpb.17.662. Biol Pharm Bull. 1994. PMID: 7920428

2

Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model.

Atsumi R, Okazaki O, Hakusui H. Atsumi R, et al. Biol Pharm Bull. 1995 Jul;18(7):1024-6. doi: 10.1248/bpb.18.1024. Biol Pharm Bull. 1995. PMID: 7581244

3

Pharmacokinetics of SN-38 [(+)-(4S)-4,11-diethyl-4,9-dihydroxy-1H- pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione], an active metabolite of irinotecan, after a single intravenous dosing of 14C-SN-38 to rats.

Atsumi R, Okazaki O, Hakusui H. Atsumi R, et al. Biol Pharm Bull. 1995 Aug;18(8):1114-9. doi: 10.1248/bpb.18.1114. Biol Pharm Bull. 1995. PMID: 8535406

4

Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion.

Atsumi R, Suzuki W, Hakusui H. Atsumi R, et al. Xenobiotica. 1991 Sep;21(9):1159-69. doi: 10.3109/00498259109039556. Xenobiotica. 1991. PMID: 1788984

5

Absorption, distribution, and excretion of DJ-927, a novel orally effective taxane, in mice, dogs, and monkeys.

Ono C, Takao A, Atsumi R. Ono C, et al. Among authors: atsumi r. Biol Pharm Bull. 2004 Mar;27(3):345-51. doi: 10.1248/bpb.27.345. Biol Pharm Bull. 2004. PMID: 14993800 Free article.

6

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes.

Naito H, Ohsuki S, Atsumi R, Minami M, Mochizuki M, Hirotani K, Kumazawa E, Ejima A. Naito H, et al. Among authors: atsumi r. Chem Pharm Bull (Tokyo). 2005 Feb;53(2):153-63. doi: 10.1248/cpb.53.153. Chem Pharm Bull (Tokyo). 2005. PMID: 15684512 Free article.

7

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.

Naito H, Ohsuki S, Sugimori M, Atsumi R, Minami M, Nakamura Y, Ishii M, Hirotani K, Kumazawa E, Ejima A. Naito H, et al. Among authors: atsumi r. Chem Pharm Bull (Tokyo). 2002 Apr;50(4):453-62. doi: 10.1248/cpb.50.453. Chem Pharm Bull (Tokyo). 2002. PMID: 11963990 Free article.

8

Urinary metabolites of DX-8951, a novel camptothecin analog, in rats and humans.

Atsumi R, Oguma T, Yoshioka N, Konno T, Okazaki O, Fujimaki Y. Atsumi R, et al. Arzneimittelforschung. 2001;51(3):253-7. doi: 10.1055/s-0031-1300032. Arzneimittelforschung. 2001. PMID: 11304942 Clinical Trial.

9

Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.

Shimizu S, Atsumi R, Nakazawa T, Izumi T, Sudo K, Okazaki O, Saji H. Shimizu S, et al. Among authors: atsumi r. Arch Toxicol. 2011 Apr;85(4):347-53. doi: 10.1007/s00204-010-0594-9. Epub 2010 Sep 25. Arch Toxicol. 2011. PMID: 20871981

10

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O. Nakayama S, et al. Among authors: atsumi r. Drug Metab Dispos. 2009 Sep;37(9):1970-7. doi: 10.1124/dmd.109.027797. Epub 2009 Jun 1. Drug Metab Dispos. 2009. PMID: 19487250

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