Austin CP - Search Results

1

Fluorescence spectroscopic profiling of compound libraries.

Simeonov A, Jadhav A, Thomas CJ, Wang Y, Huang R, Southall NT, Shinn P, Smith J, Austin CP, Auld DS, Inglese J. Simeonov A, et al. Among authors: austin cp. J Med Chem. 2008 Apr 24;51(8):2363-71. doi: 10.1021/jm701301m. Epub 2008 Mar 26. J Med Chem. 2008. PMID: 18363325

2

Characterization of chemical libraries for luciferase inhibitory activity.

Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Auld DS, et al. Among authors: austin cp. J Med Chem. 2008 Apr 24;51(8):2372-86. doi: 10.1021/jm701302v. Epub 2008 Mar 26. J Med Chem. 2008. PMID: 18363348

3

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.

Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. Auld DS, et al. Among authors: austin cp. J Med Chem. 2009 Mar 12;52(5):1450-8. doi: 10.1021/jm8014525. J Med Chem. 2009. PMID: 19215089 Free PMC article.

4

Monitoring compound integrity with cytochrome P450 assays and qHTS.

MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS. MacArthur R, et al. Among authors: austin cp. J Biomol Screen. 2009 Jun;14(5):538-46. doi: 10.1177/1087057109336954. Epub 2009 May 29. J Biomol Screen. 2009. PMID: 19483146 Free PMC article.

5

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Jadhav A, et al. Among authors: austin cp. J Med Chem. 2010 Jan 14;53(1):37-51. doi: 10.1021/jm901070c. J Med Chem. 2010. PMID: 19908840 Free PMC article.

6

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. Mott BT, et al. Among authors: austin cp. J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a. J Med Chem. 2010. PMID: 19908842 Free PMC article.

7

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Boxer MB, et al. Among authors: austin cp. J Med Chem. 2010 Feb 11;53(3):1048-55. doi: 10.1021/jm901577g. J Med Chem. 2010. PMID: 20017496 Free PMC article.

8

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP. Inglese J, et al. Among authors: austin cp. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8. doi: 10.1073/pnas.0604348103. Epub 2006 Jul 24. Proc Natl Acad Sci U S A. 2006. PMID: 16864780 Free PMC article.

9

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.

Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J. Auld DS, et al. Among authors: austin cp. Methods Enzymol. 2006;414:566-89. doi: 10.1016/S0076-6879(06)14029-X. Methods Enzymol. 2006. PMID: 17110211

10

A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor.

Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. Davis RE, et al. Among authors: austin cp. Assay Drug Dev Technol. 2007 Feb;5(1):85-103. doi: 10.1089/adt.2006.048. Assay Drug Dev Technol. 2007. PMID: 17355202

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