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138 results

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B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma.
Cui Y, Li J, Zhang P, Yin D, Wang Z, Dai J, Wang W, Zhang E, Guo R. Cui Y, et al. J Exp Clin Cancer Res. 2023 Jun 12;42(1):146. doi: 10.1186/s13046-023-02711-3. J Exp Clin Cancer Res. 2023. PMID: 37303063 Free PMC article.
RESULTS: B4GALT1, a key gene involved in N-glycan biosynthesis, was highly expressed in IAC samples. ...In addition, B4GALT1 stabilized the TAZ protein via glycosylation, which activated CD274 at the transcriptional level. ...
RESULTS: B4GALT1, a key gene involved in N-glycan biosynthesis, was highly expressed in IAC samples. ...In addition, B4GALT1 s …
B4GALT1 as a New Biomarker of Idiopathic Pulmonary Fibrosis.
De Vitis C, D'Ascanio M, Sacconi A, Pizzirusso D, Salvati V, Mancini M, Scafetta G, Cirombella R, Ascenzi F, Bruschini S, Esposito A, Castelli S, Salvucci C, Teodonio L, Sposato B, Catizone A, Di Napoli A, Vecchione A, Ciliberto G, Sciacchitano S, Ricci A, Mancini R. De Vitis C, et al. Int J Mol Sci. 2022 Nov 30;23(23):15040. doi: 10.3390/ijms232315040. Int J Mol Sci. 2022. PMID: 36499368 Free PMC article.
There are no accurate biomarkers available so far. Our aim was to evaluate the expression of the B4GALT1 in patients with IPF. Analysis of B4GALT1 gene expression was performed in silico on two gene sets, retrieved from the Gene Expression Omnibus database. ...Netwo …
There are no accurate biomarkers available so far. Our aim was to evaluate the expression of the B4GALT1 in patients with IPF. Analys …
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway.
Chen PD, Liao YY, Cheng YC, Wu HY, Wu YM, Huang MC. Chen PD, et al. Oncogenesis. 2023 Oct 31;12(1):49. doi: 10.1038/s41389-023-00494-y. Oncogenesis. 2023. PMID: 37907465 Free PMC article.
Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expressed in the liver, and patients with mutations in B4GALT1 exhibit hepatopathy. ...Moreover, B4GALT1 knockdown or knockout increased cell …
Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expressed in th …
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo.
Wang P, Li X, Xie Y. Wang P, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820980104. doi: 10.1177/1533033820980104. Technol Cancer Res Treat. 2020. PMID: 33287670 Free PMC article.
Our study was designed to investigate the role of B4GalT1 in glioblastoma, in vitro and in vivo, to detect whether B4GalT1 knockdown could regulate the development of glioblastoma, and further observe the relationship between B4GalT1 knockdown and the apoptos …
Our study was designed to investigate the role of B4GalT1 in glioblastoma, in vitro and in vivo, to detect whether B4GalT1 kno …
High expression of B4GALT1 is associated with poor prognosis in acute myeloid leukemia.
Ren Z, Huang X, Lv Q, Lei Y, Shi H, Wang F, Wang M. Ren Z, et al. Front Genet. 2022 Dec 9;13:882004. doi: 10.3389/fgene.2022.882004. eCollection 2022. Front Genet. 2022. PMID: 36568388 Free PMC article.
The nomogram obtained by Cox analysis predicts the effect of B4GALT1 on the prognosis. To assess B4GALT1-related genes' enrichment pathway and function and the correlation between B4GALT1 and immune features, GO/KEGG, protein-protein interaction network, and …
The nomogram obtained by Cox analysis predicts the effect of B4GALT1 on the prognosis. To assess B4GALT1-related genes' enrich …
LncRNA B4GALT1-AS1 promotes non-small cell lung cancer cell growth via increasing ZEB1 level by sponging miR-144-3p.
Liu SW, Yang P, Li FN, Dou RG, Liu JX, Liu GJ. Liu SW, et al. Transl Cancer Res. 2022 Mar;11(3):538-547. doi: 10.21037/tcr-22-296. Transl Cancer Res. 2022. PMID: 35402178 Free PMC article.
RESULTS: We showed significant upregulation of B4GALT1-AS1 in cell lines and tissues of NSCLC. B4GALT1-AS1 knockdown impeded the in vitro proliferation-related characteristics of the NSCLC cells. ...The B4GALT1-AS1 and miR-144-3p interaction was shown by usin …
RESULTS: We showed significant upregulation of B4GALT1-AS1 in cell lines and tissues of NSCLC. B4GALT1-AS1 knockdown impeded t …
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).
Chen Y, Su L, Huang C, Wu S, Qiu X, Zhao X, Meng Q, Meng YM, Kong X, Wang M, Liu C, Wong PP. Chen Y, et al. Cancer Lett. 2021 Mar 1;500:228-243. doi: 10.1016/j.canlet.2020.12.006. Epub 2020 Dec 9. Cancer Lett. 2021. PMID: 33309857
However, the role of glycogene, such as galactosyltransferase, in pancreatic cancer remains unknown. Herein, we establish beta-1.4-galactosyltransferase 1 (B4GALT1) as a clinical marker and regulator of chemoresistance. Clinically, high B4GALT1 expression correlates …
However, the role of glycogene, such as galactosyltransferase, in pancreatic cancer remains unknown. Herein, we establish beta-1.4-galactosy …
lncRNA B4GALT1-AS1 promotes colon cancer cell stemness and migration by recruiting YAP to the nucleus and enhancing YAP transcriptional activity.
Zhang Y, Fang Z, Guo X, Dong H, Zhou K, Huang Z, Xiao Z. Zhang Y, et al. J Cell Physiol. 2019 Aug;234(10):18524-18534. doi: 10.1002/jcp.28489. Epub 2019 Mar 25. J Cell Physiol. 2019. PMID: 30912138
Mechanistically, RNA-sequencing data found that the Hippo pathway in cancer was shown on pathways mostly upregulated by B4GALT1-AS1 knockdown, and B4GALT1-AS1 directly bound to the yes-associated protein (YAP), a downstream executor of the Hippo pathway, and B4GA …
Mechanistically, RNA-sequencing data found that the Hippo pathway in cancer was shown on pathways mostly upregulated by B4GALT1-AS1 k …
B4GALT1-congenital disorders of glycosylation: Expansion of the phenotypic and molecular spectrum and review of the literature.
Staretz-Chacham O, Noyman I, Wormser O, Abu Quider A, Hazan G, Morag I, Hadar N, Raymond K, Birk OS, Ferreira CR, Koifman A. Staretz-Chacham O, et al. Clin Genet. 2020 Jun;97(6):920-926. doi: 10.1111/cge.13735. Epub 2020 Mar 16. Clin Genet. 2020. PMID: 32157688
A congenital disorder of glycosylation due to biallelic mutations in B4GALT1 has been previously reported in only three patients with two different mutations. ...The novel mutation is the third disease-causing variant described in B4GALT1, and the first one within i …
A congenital disorder of glycosylation due to biallelic mutations in B4GALT1 has been previously reported in only three patients with …
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Xie H, Zhu Y, Zhang J, Liu Z, Fu H, Cao Y, Li G, Shen Y, Dai B, Xu J, Ye D. Xie H, et al. BMC Cancer. 2018 May 24;18(1):590. doi: 10.1186/s12885-018-4497-0. BMC Cancer. 2018. PMID: 29793447 Free PMC article.
Inclusion of B4GALT1 in the prognostic model revealed a greater predictive accuracy than the primary models. ...Most significantly, the advantage of ACT noted in pT3/4 or N+ bladder cancer patients with low B4GALT1 expression was greater than in patients with a high …
Inclusion of B4GALT1 in the prognostic model revealed a greater predictive accuracy than the primary models. ...Most significantly, t …
138 results