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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 2
1998 8
1999 2
2000 3
2001 8
2002 13
2003 11
2004 18
2005 8
2006 27
2007 22
2008 18
2009 18
2010 17
2011 20
2012 22
2013 17
2014 25
2015 36
2016 32
2017 49
2018 35
2019 51
2020 47
2021 77
2022 72
2023 71
2024 22

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677 results

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Page 1
Moderate penetrance genes complicate genetic testing for breast cancer diagnosis: ATM, CHEK2, BARD1 and RAD51D.
Graffeo R, Rana HQ, Conforti F, Bonanni B, Cardoso MJ, Paluch-Shimon S, Pagani O, Goldhirsch A, Partridge AH, Lambertini M, Garber JE. Graffeo R, et al. Breast. 2022 Oct;65:32-40. doi: 10.1016/j.breast.2022.06.003. Epub 2022 Jun 18. Breast. 2022. PMID: 35772246 Free PMC article. Review.
Germline PVs in BRCA1 and BRCA2 play important roles in the development of breast and ovarian cancer in particular, as well as in other cancers such as pancreatic and prostate cancers and melanoma. Recent studies suggest that other cancer susceptibilit …
Germline PVs in BRCA1 and BRCA2 play important roles in the development of breast and ovarian cancer in particular, as well as in oth …
BARD1 mystery: tumor suppressors are cancer susceptibility genes.
Hawsawi YM, Shams A, Theyab A, Abdali WA, Hussien NA, Alatwi HE, Alzahrani OR, Oyouni AAA, Babalghith AO, Alreshidi M. Hawsawi YM, et al. BMC Cancer. 2022 Jun 1;22(1):599. doi: 10.1186/s12885-022-09567-4. BMC Cancer. 2022. PMID: 35650591 Free PMC article. Review.
The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. ...However, there are abundant BARD1 isoforms exist …
The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer …
Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
Ramus SJ, Song H, Dicks E, Tyrer JP, Rosenthal AN, Intermaggio MP, Fraser L, Gentry-Maharaj A, Hayward J, Philpott S, Anderson C, Edlund CK, Conti D, Harrington P, Barrowdale D, Bowtell DD, Alsop K, Mitchell G; AOCS Study Group; Cicek MS, Cunningham JM, Fridley BL, Alsop J, Jimenez-Linan M, Poblete S, Lele S, Sucheston-Campbell L, Moysich KB, Sieh W, McGuire V, Lester J, Bogdanova N, Dürst M, Hillemanns P; Ovarian Cancer Association Consortium; Odunsi K, Whittemore AS, Karlan BY, Dörk T, Goode EL, Menon U, Jacobs IJ, Antoniou AC, Pharoah PD, Gayther SA. Ramus SJ, et al. J Natl Cancer Inst. 2015 Aug 27;107(11):djv214. doi: 10.1093/jnci/djv214. Print 2015 Nov. J Natl Cancer Inst. 2015. PMID: 26315354 Free PMC article.
METHODS: Next generation sequencing was used to identify germline mutations in the coding regions of four candidate susceptibility genes-BRIP1, BARD1, PALB2 and NBN-in 3236 invasive EOC case patients and 3431 control patients of European origin, and in 2000 unaffected high …
METHODS: Next generation sequencing was used to identify germline mutations in the coding regions of four candidate susceptibility genes-BRI …
Dualistic Role of BARD1 in Cancer.
Cimmino F, Formicola D, Capasso M. Cimmino F, et al. Genes (Basel). 2017 Dec 8;8(12):375. doi: 10.3390/genes8120375. Genes (Basel). 2017. PMID: 29292755 Free PMC article. Review.
Indeed, whereas FL BARD1 protein acts as tumor-suppressor with and without BRCA1 interactions, aberrant splice variants of BARD1 have been detected in various cancers and have been shown to play an oncogenic role. ...This review is an overview of how BARD1 …
Indeed, whereas FL BARD1 protein acts as tumor-suppressor with and without BRCA1 interactions, aberrant splice variants of BARD1 …
Cancer genetics and breast cancer.
Huber-Keener KJ. Huber-Keener KJ. Best Pract Res Clin Obstet Gynaecol. 2022 Jun;82:3-11. doi: 10.1016/j.bpobgyn.2022.01.007. Epub 2022 Jan 31. Best Pract Res Clin Obstet Gynaecol. 2022. PMID: 35272929 Review.
This chapter focuses on how genes play a role in breast cancer risk, why certain genes are commonly involved in hereditary breast cancer, and what are the specific genes and genetic syndromes that put patients at risk for breast cancer. Hereditary cancer …
This chapter focuses on how genes play a role in breast cancer risk, why certain genes are commonly involved in hereditary breast …
BARD1 and Breast Cancer: The Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women.
Śniadecki M, Brzeziński M, Darecka K, Klasa-Mazurkiewicz D, Poniewierza P, Krzeszowiec M, Kmieć N, Wydra D. Śniadecki M, et al. Genes (Basel). 2020 Oct 24;11(11):1251. doi: 10.3390/genes11111251. Genes (Basel). 2020. PMID: 33114377 Free PMC article. Review.
Our work is focused on the one of these genes, BRCA1-associated RING domain protein 1 (BARD1), and its oncogenic role in breast cancer. Most importantly, the study points to new avenues in the treatment and prevention of the most frequent female cancer based …
Our work is focused on the one of these genes, BRCA1-associated RING domain protein 1 (BARD1), and its oncogenic role in breast ca …
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators. DiSilvestro P, et al. J Clin Oncol. 2023 Jan 20;41(3):609-617. doi: 10.1200/JCO.22.01549. Epub 2022 Sep 9. J Clin Oncol. 2023. PMID: 36082969 Free PMC article. Clinical Trial.
METHODS: This double-blind phase III trial randomly assigned patients with newly diagnosed advanced ovarian cancer and a BRCA mutation in clinical response to platinum-based chemotherapy to maintenance olaparib (n = 260) or placebo (n = 131) for up to 2 years. ...CONCLUSIO …
METHODS: This double-blind phase III trial randomly assigned patients with newly diagnosed advanced ovarian cancer and a BRCA mutatio …
Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers.
Alenezi WM, Fierheller CT, Recio N, Tonin PN. Alenezi WM, et al. Genes (Basel). 2020 Jul 27;11(8):856. doi: 10.3390/genes11080856. Genes (Basel). 2020. PMID: 32726901 Free PMC article. Review.
Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cancer risk genes for hereditary breast and/or ovarian cancer. ...In conclusion, BARD1 is likely to be a low-moderate penetranc …
Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cance …
Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management.
Yoshimura A, Imoto I, Iwata H. Yoshimura A, et al. Int J Mol Sci. 2022 Jul 5;23(13):7481. doi: 10.3390/ijms23137481. Int J Mol Sci. 2022. PMID: 35806485 Free PMC article. Review.
Approximately 5-10% of all breast cancer (BC) cases are caused by germline pathogenic variants (GPVs) in various cancer predisposition genes (CPGs). The most common contributors to hereditary BC are BRCA1 and BRCA2, which are associated with hereditary breast and ov …
Approximately 5-10% of all breast cancer (BC) cases are caused by germline pathogenic variants (GPVs) in various cancer predis …
Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Hu Q, Botuyan MV, Zhao D, Cui G, Mer E, Mer G. Hu Q, et al. Nature. 2021 Aug;596(7872):438-443. doi: 10.1038/s41586-021-03716-8. Epub 2021 Jul 28. Nature. 2021. PMID: 34321665 Free PMC article.
These findings elucidate the mechanisms of BRCA1-BARD1 chromatin recruitment and ubiquitylation specificity, highlight key functions of BARD1 in both processes and explain how BRCA1-BARD1 promotes homologous recombination by opposing the DNA repair protein 53 …
These findings elucidate the mechanisms of BRCA1-BARD1 chromatin recruitment and ubiquitylation specificity, highlight key functions …
677 results