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PI3Kβ plays a critical role in neutrophil activation by immune complexes.
Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F, Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT. Kulkarni S, et al. Sci Signal. 2011 Apr 12;4(168):ra23. doi: 10.1126/scisignal.2001617. Sci Signal. 2011. PMID: 21487106
PI3K: from the bench to the clinic and back.
Vanhaesebroeck B, Vogt PK, Rommel C. Vanhaesebroeck B, et al. Curr Top Microbiol Immunol. 2010;347:1-19. doi: 10.1007/82_2010_65. Curr Top Microbiol Immunol. 2010. PMID: 20549473 Free PMC article. Review.
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B. Guillermet-Guibert J, et al. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. doi: 10.1073/pnas.0707761105. Epub 2008 Jun 10. Proc Natl Acad Sci U S A. 2008. PMID: 18544649 Free PMC article.
11 results