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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2001 2
2002 2
2003 2
2004 1
2005 4
2006 5
2007 7
2008 5
2009 5
2010 5
2011 3
2012 4
2013 6
2014 9
2015 11
2016 12
2017 12
2018 14
2019 24
2020 12
2021 28
2022 14
2023 15
2024 6

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193 results

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Page 1
A novel beta-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
Tanton H, Sewastianik T, Seo HS, Remillard D, Pierre RS, Bala P, Aitymbayev D, Dennis P, Adler K, Geffken E, Yeoh Z, Vangos N, Garbicz F, Scott D, Sethi N, Bradner J, Dhe-Paganon S, Carrasco RD. Tanton H, et al. Sci Adv. 2022 Apr 29;8(17):eabm3108. doi: 10.1126/sciadv.abm3108. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486727 Free PMC article.
Dysregulated Wnt/beta-catenin signaling is implicated in the pathogenesis of many human cancers, including colorectal cancer (CRC), making it an attractive clinical target. With the aim of inhibiting oncogenic Wnt activity, we developed a high-throughput screening A …
Dysregulated Wnt/beta-catenin signaling is implicated in the pathogenesis of many human cancers, including colorectal cancer ( …
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/beta-catenin signaling activation (Review).
Katoh M. Katoh M. Int J Mol Med. 2018 Aug;42(2):713-725. doi: 10.3892/ijmm.2018.3689. Epub 2018 May 17. Int J Mol Med. 2018. PMID: 29786110 Free PMC article. Review.
Gain-of-function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss-of-function CTNNB1 mutations …
Gain-of-function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer …
BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
Feng M, Wu Z, Zhou Y, Wei Z, Tian E, Mei S, Zhu Y, Liu C, He F, Li H, Xie C, Jin J, Dong J, Yang D, Yu K, Qian J, Lambrechts D, Wang MW, Zhu D. Feng M, et al. Signal Transduct Target Ther. 2021 Aug 20;6(1):313. doi: 10.1038/s41392-021-00730-0. Signal Transduct Target Ther. 2021. PMID: 34417435 Free PMC article.
By genetic depletion and pharmacological inhibition of BCL9 in tumors, we found that BCL9 suppression reduced tumor growth, promoted CD8(+) T cell tumor infiltration, and enhanced response to anti-PD-1 treatment in mouse colon cancer models. ...In The Canc …
By genetic depletion and pharmacological inhibition of BCL9 in tumors, we found that BCL9 suppression reduced tumor growth, pr …
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins.
Jiang M, Kang Y, Sewastianik T, Wang J, Tanton H, Alder K, Dennis P, Xin Y, Wang Z, Liu R, Zhang M, Huang Y, Loda M, Srivastava A, Chen R, Liu M, Carrasco RD. Jiang M, et al. Nat Commun. 2020 Jan 7;11(1):19. doi: 10.1038/s41467-019-13842-7. Nat Commun. 2020. PMID: 31911584 Free PMC article.
Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. ...These data provide additional insights into the role of BCL9 in tumor pathogen …
Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incur …
Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives.
Wang Z, Li Z, Ji H. Wang Z, et al. Med Res Rev. 2021 Jul;41(4):2109-2129. doi: 10.1002/med.21787. Epub 2021 Jan 21. Med Res Rev. 2021. PMID: 33475177 Free PMC article. Review.
Aberrant activation of the Wnt/beta-catenin signaling circuit is associated with cancer recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion. ...
Aberrant activation of the Wnt/beta-catenin signaling circuit is associated with cancer recurrence and relapse, cancer invasio …
Bcl9 Depletion Modulates Endothelial Cell in Tumor Immune Microenvironment in Colorectal Cancer Tumor.
Wei Z, Feng M, Wu Z, Shen S, Zhu D. Wei Z, et al. Front Oncol. 2021 Jan 19;10:603702. doi: 10.3389/fonc.2020.603702. eCollection 2020. Front Oncol. 2021. PMID: 33552975 Free PMC article.
Furthermore, we propose a BCL9-endo-Score based on the differential expression of cells related to different states of BCL9 functions. Using published data sets with normal endothelial cells, we found that this score can characterize endothelial cells at different s …
Furthermore, we propose a BCL9-endo-Score based on the differential expression of cells related to different states of BCL9 fu …
Recent advances in beta-catenin/BCL9 protein-protein interaction inhibitors.
Zhang H, Bao Y, Liu C, Li J, Zhu D, Zhang Q. Zhang H, et al. Future Med Chem. 2021 May;13(10):927-940. doi: 10.4155/fmc-2020-0357. Epub 2021 Apr 14. Future Med Chem. 2021. PMID: 33849283 Review.
Moreover, aberrant Wnt signaling has been associated with various diseases, especially cancer and fibrosis. Recent research suggests that direct targeting of the beta-catenin/BCL9 protein-protein interaction (PPI) is a promising strategy to block the Wnt pathway. .. …
Moreover, aberrant Wnt signaling has been associated with various diseases, especially cancer and fibrosis. Recent research suggests …
BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
Wang X, Feng M, Xiao T, Guo B, Liu D, Liu C, Pei J, Liu Q, Xiao Y, Rosin-Arbesfeld R, Shi Y, Zhou Y, Yang M, Feng YX, Jiang Y, Shao Z, Yu K, Zhu D. Wang X, et al. Oncogene. 2021 Apr;40(16):2982-2997. doi: 10.1038/s41388-021-01756-y. Epub 2021 Mar 25. Oncogene. 2021. PMID: 33767438
Here we demonstrate that the expression of BCL9 and BCL9L is directly correlated with malignancy in TNBC patient tumors and that BCL9 and BCL9L promote tumor cell growth, cell migration and metastasis in TNBC models. ...In summary, these results suggest that targeti …
Here we demonstrate that the expression of BCL9 and BCL9L is directly correlated with malignancy in TNBC patient tumors and that B …
Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer.
Yang M, Wei Z, Feng M, Zhu Y, Chen Y, Zhu D. Yang M, et al. Front Oncol. 2021 May 5;11:603556. doi: 10.3389/fonc.2021.603556. eCollection 2021. Front Oncol. 2021. PMID: 34026600 Free PMC article.
Cancer-associated fibroblasts (CAFs) exert a key role in cancer progression and liver metastasis. ...In summary, we demonstrate cell type landscape and transcription difference upon BCL9 suppression in CAFs, as well as how CAF affects cancer associated …
Cancer-associated fibroblasts (CAFs) exert a key role in cancer progression and liver metastasis. ...In summary, we demonstrat …
The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.
Vafaizadeh V, Buechel D, Rubinstein N, Kalathur RKR, Bazzani L, Saxena M, Valenta T, Hausmann G, Cantù C, Basler K, Christofori G. Vafaizadeh V, et al. Oncogene. 2021 Oct;40(43):6195-6209. doi: 10.1038/s41388-021-02016-9. Epub 2021 Sep 20. Oncogene. 2021. PMID: 34545187 Free PMC article.
Canonical Wnt/beta-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malignant tumor progression and metastasis formation have been demonstrated in various cancer types. Here, we investigated how the binding …
Canonical Wnt/beta-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malig …
193 results