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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 1
2007 1
2008 3
2009 1
2010 2
2011 3
2012 5
2013 2
2014 7
2015 4
2016 8
2017 3
2018 4
2019 7
2020 6
2021 7
2022 5
2023 4
2024 3

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Page 1
METTL3 Inhibits Antitumor Immunity by Targeting m(6)A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer.
Chen H, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H, Wang Y, Kang W, Kei Wu WK, Yu J. Chen H, et al. Gastroenterology. 2022 Oct;163(4):891-907. doi: 10.1053/j.gastro.2022.06.024. Epub 2022 Jun 11. Gastroenterology. 2022. PMID: 35700773 Free article.
METTL3 promoted BHLHE41 expression in an m(6)A-dependent manner, which subsequently induced CXCL1 transcription to enhance MDSC migration in vitro. However, the effect was negligible on BHLHE41 depletion, CXCL1 protein or CXCR2 inhibitor SB265610 administration, inf …
METTL3 promoted BHLHE41 expression in an m(6)A-dependent manner, which subsequently induced CXCL1 transcription to enhance MDSC migra …
Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development.
Furukawa T, Mimami K, Nagata T, Yamamoto M, Sato M, Tanimoto A. Furukawa T, et al. Int J Mol Sci. 2023 Jul 21;24(14):11731. doi: 10.3390/ijms241411731. Int J Mol Sci. 2023. PMID: 37511489 Free PMC article. Review.
BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation mo …
BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The eff …
BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.
Nagata T, Minami K, Yamamoto M, Hiraki T, Idogawa M, Fujimoto K, Kageyama S, Tabata K, Kawahara K, Ueda K, Ikeda R, Kato Y, Komatsu M, Tanimoto A, Furukawa T, Sato M. Nagata T, et al. Int J Mol Sci. 2021 Oct 26;22(21):11509. doi: 10.3390/ijms222111509. Int J Mol Sci. 2021. PMID: 34768959 Free PMC article.
Lung cancer constitutes a threat to human health. BHLHE41 plays important roles in circadian rhythm and cell differentiation as a negative regulatory transcription factor. This study investigates the role of BHLHE41 in lung cancer progression. We analy …
Lung cancer constitutes a threat to human health. BHLHE41 plays important roles in circadian rhythm and cell differentiation a …
BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1alpha/EMT Pathway.
Chen S, Dong QJ, Wan ZA, Gao S, Tu SL, Chai R. Chen S, et al. Gastroenterol Res Pract. 2022 May 16;2022:6972331. doi: 10.1155/2022/6972331. eCollection 2022. Gastroenterol Res Pract. 2022. PMID: 35615737 Free PMC article.
OBJECTIVE: BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mucosa. ...After, CC cells were subjected to hypoxia treatment and BHLHE41 overexpression transfection, and the BHLHE41 expressi …
OBJECTIVE: BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mu …
BHLHE41 inhibits bladder cancer progression via regulation of PYCR1 stability and thus inactivating PI3K/AKT signaling pathway.
Xiao S, Chen J, Wei Y, Song W. Xiao S, et al. Eur J Med Res. 2024 May 29;29(1):302. doi: 10.1186/s40001-024-01889-2. Eur J Med Res. 2024. PMID: 38811952 Free PMC article.
RESULTS: In this study, we found that BHLHE41 was lowly expressed in bladder cancer tissues and cell lines, and lower expression of BHLHE41 was associated with poor overall survival in bladder cancer patients. ...CONCLUSION: BHLHE41 might be a u …
RESULTS: In this study, we found that BHLHE41 was lowly expressed in bladder cancer tissues and cell lines, and lower expressi …
BHLHE41 suppresses MCF-7 cell invasion via MAPK/JNK pathway.
Zhang D, Zheng Q, Wang C, Zhao N, Liu Y, Wang E. Zhang D, et al. J Cell Mol Med. 2020 Apr;24(7):4001-4010. doi: 10.1111/jcmm.15033. Epub 2020 Feb 19. J Cell Mol Med. 2020. PMID: 32073238 Free PMC article.
Deregulation of the basic helix-loop-helix family member e41 (BHLHE41) has been characterized as a marker of progression of several cancers. In this study, we aimed to explore the mechanism by which BHLHE41 regulates the invasion of breast cancer cells …
Deregulation of the basic helix-loop-helix family member e41 (BHLHE41) has been characterized as a marker of progression of several …
Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells.
Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K. Asanoma K, et al. Mol Cell Biol. 2015 Dec;35(24):4096-109. doi: 10.1128/MCB.00678-15. Epub 2015 Sep 21. Mol Cell Biol. 2015. PMID: 26391953 Free PMC article.
BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors. ...In the present study, we demonstrated that BHLHE40/41 expression was controlled in a pathological stage-dependent manner in human endom …
BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors …
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41.
Bigot P, Colli LM, Machiela MJ, Jessop L, Myers TA, Carrouget J, Wagner S, Roberson D, Eymerit C, Henrion D, Chanock SJ. Bigot P, et al. Nat Commun. 2016 Jul 7;7:12098. doi: 10.1038/ncomms12098. Nat Commun. 2016. PMID: 27384883 Free PMC article.
Luciferase assays demonstrate allele-specific regulatory activity and, together with data from electromobility shift assays, suggest allele-specific differences at rs7132434 for AP-1 transcription factor binding. In an analysis of The Cancer Genome Atlas data, SNPs highly …
Luciferase assays demonstrate allele-specific regulatory activity and, together with data from electromobility shift assays, suggest allele- …
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.
Nassar AH, Abou Alaiwi S, Baca SC, Adib E, Corona RI, Seo JH, Fonseca MAS, Spisak S, El Zarif T, Tisza V, Braun DA, Du H, He M, Flaifel A, Alchoueiry M, Denize T, Matar SG, Acosta A, Shukla S, Hou Y, Steinharter J, Bouchard G, Berchuck JE, O'Connor E, Bell C, Nuzzo PV, Mary Lee GS, Signoretti S, Hirsch MS, Pomerantz M, Henske E, Gusev A, Lawrenson K, Choueiri TK, Kwiatkowski DJ, Freedman ML. Nassar AH, et al. Nat Commun. 2023 Jan 21;14(1):346. doi: 10.1038/s41467-023-35833-5. Nat Commun. 2023. PMID: 36681680 Free PMC article.
We confirm histology-specific MTFs via immunohistochemistry including a ccRCC-specific TF, BHLHE41. FOXI1 overexpression with knock-down of EPAS1 in the 786-O ccRCC cell line induces transcriptional upregulation of chRCC-specific genes, TFCP2L1, ATP6V0D2, KIT, and INSRR, i …
We confirm histology-specific MTFs via immunohistochemistry including a ccRCC-specific TF, BHLHE41. FOXI1 overexpression with knock-d …
Overexpression of BHLHE41, correlated with DNA hypomethylation in 3'UTR region, promotes the growth of human clear cell renal cell carcinoma.
Shen Z, Zhu L, Zhang C, Cui X, Lu J. Shen Z, et al. Oncol Rep. 2019 Apr;41(4):2137-2147. doi: 10.3892/or.2019.7004. Epub 2019 Feb 7. Oncol Rep. 2019. PMID: 30816499 Free PMC article.
The aim of the present study was to analyze the expression of BHLHE41 in ccRCC and investigate the effect of downregulated BHLHE41 on the growth and migration of ccRCC cells. ...Additionally, a lower frequency methylation was determined in the BHLHE41 3'-untr …
The aim of the present study was to analyze the expression of BHLHE41 in ccRCC and investigate the effect of downregulated BHLHE41 …
75 results