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2002 2
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2012 6
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2017 4
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108 results

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BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition.
Niu W, Luo Y, Zhou Y, Li M, Wu C, Duan Y, Wang H, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Li H, Zhou M. Niu W, et al. J Exp Clin Cancer Res. 2020 Feb 7;39(1):30. doi: 10.1186/s13046-019-1493-4. J Exp Clin Cancer Res. 2020. PMID: 32028981 Free PMC article.
BACKGROUND: BRD7 is a tumor suppressor known to inhibit cell proliferation and cell cycle progression and initiate apoptosis in breast cancer. ...Additionally, BRD7 expression was negatively correlated with the level of YB1 in breast cancer patients. . …
BACKGROUND: BRD7 is a tumor suppressor known to inhibit cell proliferation and cell cycle progression and initiate apoptosis in breas …
The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells.
Zhang Z, Guo M, Shen M, Kong D, Zhang F, Shao J, Tan S, Wang S, Chen A, Cao P, Zheng S. Zhang Z, et al. Redox Biol. 2020 Sep;36:101619. doi: 10.1016/j.redox.2020.101619. Epub 2020 Jun 24. Redox Biol. 2020. PMID: 32863216 Free PMC article.
CRISPR/Cas9-mediated BRD7 knockout conferred resistance to HSC ferroptosis, whereas specific BRD7 plasmid-mediated BRD7 overexpression facilitated HSC ferroptosis. ...HSC-specific blockade of BRD7-P53-SLC25A28 axis could abrogate erastin-induced HSC fe …
CRISPR/Cas9-mediated BRD7 knockout conferred resistance to HSC ferroptosis, whereas specific BRD7 plasmid-mediated BRD7 …
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.
Shu S, Wu HJ, Ge JY, Zeid R, Harris IS, Jovanović B, Murphy K, Wang B, Qiu X, Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao T, Reddy Chilamakuri CS, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen QD, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F, Polyak K. Shu S, et al. Mol Cell. 2020 Jun 18;78(6):1096-1113.e8. doi: 10.1016/j.molcel.2020.04.027. Epub 2020 May 15. Mol Cell. 2020. PMID: 32416067 Free PMC article.
BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs limits their potential clinical use. ...We also uncovered functional similarities and d …
BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer …
Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer.
Li X, Wang Y, Deng S, Zhu G, Wang C, Johnson NA, Zhang Z, Tirado CR, Xu Y, Metang LA, Gonzalez J, Mukherji A, Ye J, Yang Y, Peng W, Tang Y, Hofstad M, Xie Z, Yoon H, Chen L, Liu X, Chen S, Zhu H, Strand D, Liang H, Raj G, He HH, Mendell JT, Li B, Wang T, Mu P. Li X, et al. Cancer Cell. 2023 Aug 14;41(8):1427-1449.e12. doi: 10.1016/j.ccell.2023.06.010. Epub 2023 Jul 20. Cancer Cell. 2023. PMID: 37478850 Free PMC article.
The cytosine deaminase APOBEC proteins have been implicated in the mutational signatures of more than 70% of human cancers. However, the mechanism underlying how cancer cells hijack the APOBEC mediated mutagenesis machinery to promote tumor heterogeneity, and thereb …
The cytosine deaminase APOBEC proteins have been implicated in the mutational signatures of more than 70% of human cancers. However, …
BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer.
Zhao R, Liu Y, Wu C, Li M, Wei Y, Niu W, Yang J, Fan S, Xie Y, Li H, Wang W, Zeng Z, Xiong W, Li X, Li G, Zhou M. Zhao R, et al. Front Cell Dev Biol. 2021 May 24;9:659392. doi: 10.3389/fcell.2021.659392. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34109174 Free PMC article.
BRD7 functions as a crucial tumor suppressor in numerous malignancies. However, the effects of BRD7 on colorectal cancer (CRC) progression are still unknown. Here, based on the BRD7 knockout (BRD7(-/-)) and BRD7 (flox/flox) (BRD7(+ …
BRD7 functions as a crucial tumor suppressor in numerous malignancies. However, the effects of BRD7 on colorectal cancer …
BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53.
Luo Y, Wang X, Niu W, Zhou Y, Li M, Ma J, Yang J, Fan S, Zeng Z, Xiong W, Li X, Li G, Xiao J, Zhou M. Luo Y, et al. J Cancer. 2022 Feb 28;13(5):1436-1448. doi: 10.7150/jca.67447. eCollection 2022. J Cancer. 2022. PMID: 35371302 Free PMC article.
Bromodomain-containing protein 7 (BRD7) was found to be down-expressed in nasopharyngeal carcinoma as well as breast cancer and to function as a potential tumor suppressor. ...However, the mechanism how BRD7 functions as tumor suppressor roles in breast ca …
Bromodomain-containing protein 7 (BRD7) was found to be down-expressed in nasopharyngeal carcinoma as well as breast cancer an …
BRD7-Mediated miR-3148 Inhibits Progression of Cervical Cancer by Targeting Wnt3a/beta-Catenin Pathway.
Wang H, Xie Y. Wang H, et al. Reprod Sci. 2020 Mar;27(3):877-887. doi: 10.1007/s43032-019-00091-8. Epub 2020 Jan 6. Reprod Sci. 2020. PMID: 32046432
In this study, we identify that miR-3148 is downregulated in the development of cervical cancer. In cervical cancer cells, upregulated miR-3148 inhibits cell proliferation and promotes apoptosis, suggesting that miR-3148 acts as a tumor suppressor gene. ...In conclu …
In this study, we identify that miR-3148 is downregulated in the development of cervical cancer. In cervical cancer cells, upr …
BRD7: a novel tumor suppressor gene in different cancers.
Yu X, Li Z, Shen J. Yu X, et al. Am J Transl Res. 2016 Feb 15;8(2):742-8. eCollection 2016. Am J Transl Res. 2016. PMID: 27158366 Free PMC article. Review.
BRD7 is a crucial component of both functional p53 and BRCA1 (breast cancer 1, early onset) pathways. ...The expression of BRD7 was downregulated in various cancers, including breast cancer, NPC, gastric cancer, colorectal carcinoma, ovar …
BRD7 is a crucial component of both functional p53 and BRCA1 (breast cancer 1, early onset) pathways. ...The expression of …
Emerging Roles of BRD7 in Pathophysiology.
Park SW, Lee JM. Park SW, et al. Int J Mol Sci. 2020 Sep 27;21(19):7127. doi: 10.3390/ijms21197127. Int J Mol Sci. 2020. PMID: 32992509 Free PMC article. Review.
BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted. Here, we review the involvement of BRD7 in a variety of pathophysiological conditions, with …
BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism …
A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.
Pan D, Kobayashi A, Jiang P, Ferrari de Andrade L, Tay RE, Luoma AM, Tsoucas D, Qiu X, Lim K, Rao P, Long HW, Yuan GC, Doench J, Brown M, Liu XS, Wucherpfennig KW. Pan D, et al. Science. 2018 Feb 16;359(6377):770-775. doi: 10.1126/science.aao1710. Epub 2018 Jan 4. Science. 2018. PMID: 29301958 Free PMC article.
Many human cancers are resistant to immunotherapy, for reasons that are poorly understood. ...Treatment-resistant tumors became responsive to immunotherapy when Pbrm1 was inactivated. In many human cancers, expression of PBRM1 and ARID2 inversely correlated with exp …
Many human cancers are resistant to immunotherapy, for reasons that are poorly understood. ...Treatment-resistant tumors became respo …
108 results