Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2000 1
2005 1
2006 1
2007 1
2010 1
2012 1
2013 6
2014 4
2015 3
2016 12
2017 11
2018 11
2019 5
2020 6
2021 9
2022 11
2023 5
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

83 results

Results by year

Filters applied: . Clear all
Page 1
BRDT promotes ovarian cancer cell growth.
Chen L, Cai S, Wang JM, Huai YY, Lu PH, Chu Q. Chen L, et al. Cell Death Dis. 2020 Nov 30;11(11):1021. doi: 10.1038/s41419-020-03225-y. Cell Death Dis. 2020. PMID: 33257688 Free PMC article.
Downregulation of PLK1 and AURKC was detected in BRDT-knockout and BRDT-silenced tumor tissues. Collectively, BRDT overexpression promotes ovarian cancer cell progression. Targeting BRDT could be a novel strategy to treat ovarian cancer.. …
Downregulation of PLK1 and AURKC was detected in BRDT-knockout and BRDT-silenced tumor tissues. Collectively, BRDT over …
The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.
Bourova-Flin E, Chuffart F, Rousseaux S, Khochbin S. Bourova-Flin E, et al. Cell J. 2017 Spring;19(Suppl 1):1-8. doi: 10.22074/cellj.2017.5060. Epub 2017 May 17. Cell J. 2017. PMID: 28580303 Free PMC article. Review.
Here we focus on one of these genes encoding the testis-specific member of the bromodomain and extra-terminal (BET) family, known as BRDT. Aberrant activation of BRDT was first detected in lung cancers. ...Also, these functional studies of BRDT point t …
Here we focus on one of these genes encoding the testis-specific member of the bromodomain and extra-terminal (BET) family, known as BRDT …
BET proteins: Biological functions and therapeutic interventions.
Guo J, Zheng Q, Peng Y. Guo J, et al. Pharmacol Ther. 2023 Mar;243:108354. doi: 10.1016/j.pharmthera.2023.108354. Epub 2023 Feb 3. Pharmacol Ther. 2023. PMID: 36739915 Review.
Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac modification, thus controlling gene expression, remodeling chromatin structures and avoid replicative stres …
Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and BRDT) play a pivotal role in interpreting the epige …
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Faivre EJ, McDaniel KF, Albert DH, Mantena SR, Plotnik JP, Wilcox D, Zhang L, Bui MH, Sheppard GS, Wang L, Sehgal V, Lin X, Huang X, Lu X, Uziel T, Hessler P, Lam LT, Bellin RJ, Mehta G, Fidanze S, Pratt JK, Liu D, Hasvold LA, Sun C, Panchal SC, Nicolette JJ, Fossey SL, Park CH, Longenecker K, Bigelow L, Torrent M, Rosenberg SH, Kati WM, Shen Y. Faivre EJ, et al. Nature. 2020 Feb;578(7794):306-310. doi: 10.1038/s41586-020-1930-8. Epub 2020 Jan 22. Nature. 2020. PMID: 31969702
Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinities to the first (BD1) and second (BD2) bromodomains of BRD2, BRD3, BRD4 and BRDt have displayed modest clinical activity in monotherapy cancer trials. ...These results underscore the potential val …
Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinities to the first (BD1) and second (BD2) bromodomains of BRD2, BRD3, BRD …
Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Yu Z, et al. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021102118. doi: 10.1073/pnas.2021102118. Proc Natl Acad Sci U S A. 2021. PMID: 33637650 Free PMC article.
Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET) subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated contraceptive target. ...To assess the contribution of each BRDT bromodomain, we screened our collec …
Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET) subfamily that includes the cancer targets BRD2 …
Small-Molecule Targeting of BET Proteins in Cancer.
French CA. French CA. Adv Cancer Res. 2016;131:21-58. doi: 10.1016/bs.acr.2016.04.001. Epub 2016 May 31. Adv Cancer Res. 2016. PMID: 27451123 Review.
This family of proteins includes BRD2, BRD3, BRD4, and BRDT. BRD4 is the most-studied BET protein in cancer, and normally serves as an epigenetic reader that links active chromatin marks to transcriptional elongation through activation of RNA polymerase II. The role …
This family of proteins includes BRD2, BRD3, BRD4, and BRDT. BRD4 is the most-studied BET protein in cancer, and normally serv …
Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9.
Scanlan MJ, Altorki NK, Gure AO, Williamson B, Jungbluth A, Chen YT, Old LJ. Scanlan MJ, et al. Cancer Lett. 2000 Mar 31;150(2):155-64. doi: 10.1016/s0304-3835(99)00385-7. Cancer Lett. 2000. PMID: 10704737
In an effort to define new cancer-testis (CT) genes, we investigated whether BRDT, a testis-restricted member of the RING3 family of transcriptional regulators, is also expressed in cancer. Standard RT-PCR expression analysis detected BRDT transcripts …
In an effort to define new cancer-testis (CT) genes, we investigated whether BRDT, a testis-restricted member of the RING3 fam …
Bromodomain protein BRDT directs deltaNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas.
Wang X, Kutschat AP, Yamada M, Prokakis E, Böttcher P, Tanaka K, Doki Y, Hamdan FH, Johnsen SA. Wang X, et al. Cell Death Differ. 2021 Jul;28(7):2207-2220. doi: 10.1038/s41418-021-00751-w. Epub 2021 Mar 3. Cell Death Differ. 2021. PMID: 33658703 Free PMC article.
Further mechanistic insight was gained through transcriptome analyses, which revealed that BRDT controls the expression of a subset of deltaNp63 target genes. ...Interestingly, BET proteolysis-targeting chimera, MZ1, reversed the activation of these genes. Importantly, we …
Further mechanistic insight was gained through transcriptome analyses, which revealed that BRDT controls the expression of a subset o …
BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma.
Wan P, Chen Z, Zhong W, Jiang H, Huang Z, Peng D, He Q, Chen N. Wan P, et al. Oncol Rep. 2020 Dec;44(6):2475-2486. doi: 10.3892/or.2020.7796. Epub 2020 Oct 8. Oncol Rep. 2020. PMID: 33125143 Free PMC article.
As an important member of the BET family, bromodomain testis-specific protein (BRDT) has been well studied; however, the mechanism underlying BRDT in the regulation of RCC has not been fully investigated. ...It was revealed that eIF4EBP1 interacted with BRDT, …
As an important member of the BET family, bromodomain testis-specific protein (BRDT) has been well studied; however, the mechanism un …
BET Protein BRDT Complexes With HDAC1, PRMT5, and TRIM28 and Functions in Transcriptional Repression During Spermatogenesis.
Wang L, Wolgemuth DJ. Wang L, et al. J Cell Biochem. 2016 Jun;117(6):1429-38. doi: 10.1002/jcb.25433. Epub 2015 Nov 26. J Cell Biochem. 2016. PMID: 26565999 Free PMC article.
We previously showed that loss of the first bromodomain of BRDT by targeted mutagenesis (Brdt(deltaBD1) ) resulted in sterility and abnormalities in spermiogenesis, but little is known about BRDT's function at the molecular level. As part of studies designed …
We previously showed that loss of the first bromodomain of BRDT by targeted mutagenesis (Brdt(deltaBD1) ) resulted in sterilit …
83 results