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Fumarate induces vesicular release of mtDNA to drive innate immunity.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel IMN, Morris JL, Ferguson A, Chowdury SR, Segarra-Mondejar M, Costa ASH, Pereira GC, Tronci L, Young T, Nikitopoulou E, Yang M, Bihary D, Caicci F, Nagashima S, Speed A, Bokea K, Baig Z, Samarajiwa S, Tran M, Mitchell T, Johnson M, Prudent J, Frezza C. Zecchini V, et al. Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8. Nature. 2023. PMID: 36890229 Free PMC article.
Overexpression of BRINP3 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration via MAP4 in Osteosarcoma.
Zeng W, Xu H, Wei T, Liang H, Ma X, Wang F. Zeng W, et al. Dis Markers. 2022 Jul 7;2022:2698869. doi: 10.1155/2022/2698869. eCollection 2022. Dis Markers. 2022. PMID: 35845140 Free PMC article.
In vitro, downregulation of BRINP3 was able to inhibit the proliferation and invasion of osteosarcoma cell lines. Furthermore, BRINP3 interacted with microtubule-associated protein 4 (MAP4) at the protein level, and overexpression of MAP4 could partially reverse the …
In vitro, downregulation of BRINP3 was able to inhibit the proliferation and invasion of osteosarcoma cell lines. Furthermore, BRI …
BDNF/TrkB confers bortezomib resistance in multiple myeloma by inducing BRINP3.
Bao L, Wang Y, Lu M, Shi L, Chu B, Gao S. Bao L, et al. Biochim Biophys Acta Gen Subj. 2023 Mar;1867(3):130299. doi: 10.1016/j.bbagen.2022.130299. Epub 2022 Dec 21. Biochim Biophys Acta Gen Subj. 2023. PMID: 36565997 Free article.
BDNF/TrkB induced phosphorylation of STAT3 that upregulated the bone morphogenetic protein/retinoic acid inducible neural-specific 3 (BRINP3). CONCLUSIONS: BDNF/TrkB enhanced downstream pathway expression of phosphorylation STAT3 and BRINP3 molecules, promoting RPMI …
BDNF/TrkB induced phosphorylation of STAT3 that upregulated the bone morphogenetic protein/retinoic acid inducible neural-specific 3 (BRI …
Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis.
Smith PJ, Levine AP, Dunne J, Guilhamon P, Turmaine M, Sewell GW, OʼShea NR, Vega R, Paterson JC, Oukrif D, Beck S, Bloom SL, Novelli M, Rodriguez-Justo M, Smith AM, Segal AW. Smith PJ, et al. Inflamm Bowel Dis. 2014 Oct;20(10):1802-12. doi: 10.1097/MIB.0000000000000169. Inflamm Bowel Dis. 2014. PMID: 25171508 Free PMC article.
RESULTS: Only 4 probes were abnormally expressed throughout the colon in patients with UC with Bone morphogenetic protein/Retinoic acid Inducible Neural-specific 3 (BRINP3) being the most significantly underexpressed. Attenuated expression of BRINP3 in UC was indepe …
RESULTS: Only 4 probes were abnormally expressed throughout the colon in patients with UC with Bone morphogenetic protein/Retinoic acid Indu …
Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion.
Shorts-Cary L, Xu M, Ertel J, Kleinschmidt-Demasters BK, Lillehei K, Matsuoka I, Nielsen-Preiss S, Wierman ME. Shorts-Cary L, et al. Endocrinology. 2007 Mar;148(3):967-75. doi: 10.1210/en.2006-0905. Epub 2006 Nov 30. Endocrinology. 2007. PMID: 17138656
BRINP3 mRNA was expressed selectively in gonadotropinomas. Subcellular localization studies showed that BRINP3 was targeted to the mitochondria, but BRINP3 overexpression was unable to protect pituitary cells against programmed cell death induced by growth fa …
BRINP3 mRNA was expressed selectively in gonadotropinomas. Subcellular localization studies showed that BRINP3 was targeted to …
Whole exome analysis reveals the genomic profiling related to chemo-resistance in Chinese population with limited-disease small cell lung cancer.
Yu J, Zhao S, Su Z, Song C, Wu L, Wang J, Bi N, Wang L. Yu J, et al. Cancer Med. 2023 Jan;12(2):1035-1050. doi: 10.1002/cam4.4950. Epub 2022 Jun 23. Cancer Med. 2023. PMID: 35735600 Free PMC article.
PURPOSE: The mechanism of chemo-resistance in small cell lung cancer (SCLC) is unclear. This study aims to explore the resistance-related genomic profiles of residual tumors after neo-adjuvant chemotherapy (NAC) in SCLC through the whole-exome sequencing (WES). ...A total …
PURPOSE: The mechanism of chemo-resistance in small cell lung cancer (SCLC) is unclear. This study aims to explore the resistance-rel …
Transethnic and race-stratified genome-wide association study of fibroid characteristics in African American and European American women.
Bray MJ, Wellons MF, Jones SH, Torstenson ES, Edwards TL, Velez Edwards DR. Bray MJ, et al. Fertil Steril. 2018 Sep;110(4):737-745.e34. doi: 10.1016/j.fertnstert.2018.04.035. Fertil Steril. 2018. PMID: 30196971 Free PMC article.
The strongest signal for transethnic analyses was at a variant on 1q31.1 located between PLA2G4A and BRINP3 (rs6605005, beta = 0.24; 95% confidence interval 0.15, 0.33) for fibroid volume. ...
The strongest signal for transethnic analyses was at a variant on 1q31.1 located between PLA2G4A and BRINP3 (rs6605005, beta = 0.24; …
Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.
Chen L, Su L, Li J, Zheng Y, Yu B, Yu Y, Yan M, Gu Q, Zhu Z, Liu B. Chen L, et al. Dis Markers. 2012;32(3):195-202. doi: 10.3233/DMA-2011-0877. Dis Markers. 2012. PMID: 22377736 Free PMC article.
Most cases of gastric cancer (GC) are not diagnosed at early stage which can be curable, so it is necessary to identify effective biomarkers for its diagnosis and pre-warning. We have used methylated DNA immunoprecipitation (MeDIP) to identify genes that are frequently met …
Most cases of gastric cancer (GC) are not diagnosed at early stage which can be curable, so it is necessary to identify effective bio …
Mutational and Transcriptional Characterization Establishes Prognostic Models for Resectable Lung Squamous Cell Carcinoma.
Liu Y, Duan J, Zhang F, Liu F, Luo X, Shi Y, Lei Y. Liu Y, et al. Cancer Manag Res. 2023 Feb 17;15:147-163. doi: 10.2147/CMAR.S384918. eCollection 2023. Cancer Manag Res. 2023. PMID: 36824152 Free PMC article.
METHODS: Data of genomic alterations and transcriptional-level changes of 355 stage I-IIIA LUSC patients were downloaded from The Cancer Genome Atlas (TCGA) database, together with the clinicopathological information (training cohort). ...TP53 (78%), TTN (68%), CSMD3 (39%) …
METHODS: Data of genomic alterations and transcriptional-level changes of 355 stage I-IIIA LUSC patients were downloaded from The Cancer …
Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common.
Zapata I, Moraes LE, Fiala EM, Zaldivar-Lopez S, Couto CG, Rowell JL, Alvarez CE. Zapata I, et al. BMC Genomics. 2019 Mar 19;20(1):226. doi: 10.1186/s12864-019-5531-6. BMC Genomics. 2019. PMID: 30890123 Free PMC article.
BACKGROUND: Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not improved in 50 years. Osteosarcoma still has a 5-year survival rate of 66%. ...
BACKGROUND: Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not …
12 results