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BRSK1 confers cisplatin resistance in cervical cancer cells via regulation of mitochondrial respiration.
Liu G, Li L, Shang D, Zhou C, Zhang C. Liu G, et al. J Cancer Res Clin Oncol. 2023 Sep;149(11):8803-8815. doi: 10.1007/s00432-023-04821-z. Epub 2023 May 4. J Cancer Res Clin Oncol. 2023. PMID: 37140697
Moreover, BRSK1-mediated regulation of cisplatin sensitivity is conducted by a subpopulation of BRSK1 residing in the mitochondria of cervical cancer cells and is dependent on its kinase enzymatic activity. ...Of note, we observed that high BRSK1 expre …
Moreover, BRSK1-mediated regulation of cisplatin sensitivity is conducted by a subpopulation of BRSK1 residing in the mitochon …
AMPKalpha-like proteins as LKB1 downstream targets in cell physiology and cancer.
Molina E, Hong L, Chefetz I. Molina E, et al. J Mol Med (Berl). 2021 May;99(5):651-662. doi: 10.1007/s00109-021-02040-y. Epub 2021 Mar 4. J Mol Med (Berl). 2021. PMID: 33661342 Review.
One of the key events in cancer development is the ability of tumor cells to overcome nutrient deprivation and hypoxia. ...In this review, we describe LKB1 and its downstream target AMPK summarize major functions of various AMPK-like proteins, while focusing on biological …
One of the key events in cancer development is the ability of tumor cells to overcome nutrient deprivation and hypoxia. ...In this re …
Genetic variation may modify ovarian reserve in female childhood cancer survivors.
van Dorp W, van den Heuvel-Eibrink MM, Stolk L, Pieters R, Uitterlinden AG, Visser JA, Laven JS. van Dorp W, et al. Hum Reprod. 2013 Apr;28(4):1069-76. doi: 10.1093/humrep/des472. Epub 2013 Jan 29. Hum Reprod. 2013. PMID: 23360674
STUDY QUESTION: Are genetic polymorphisms, previously identified as being associated with age at menopause in the healthy population, associated with ovarian reserve and predicted age at menopause in adult long-term survivors of childhood cancer? SUMMARY ANSWER: The CT gen …
STUDY QUESTION: Are genetic polymorphisms, previously identified as being associated with age at menopause in the healthy population, associ …
LKB1 signaling and patient survival outcomes in hepatocellular carcinoma.
Nguyen K, Hebert K, McConnell E, Cullen N, Cheng T, Awoyode S, Martin E, Chen W, Wu T, Alahari SK, Izadpanah R, Collins-Burow BM, Lee SB, Drewry DH, Burow ME. Nguyen K, et al. Pharmacol Res. 2023 Jun;192:106757. doi: 10.1016/j.phrs.2023.106757. Epub 2023 Apr 5. Pharmacol Res. 2023. PMID: 37023992 Free article. Review.
Furthermore, liver cancer is the most common cause of death associated with cirrhosis and is the 3rd leading cause of global cancer deaths. ...Furthermore, LKB1 signaling has been found to be involved in many cancers with most reports identifying LKB1 to have …
Furthermore, liver cancer is the most common cause of death associated with cirrhosis and is the 3rd leading cause of global cance …
Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function.
van der Kooi ALF, van Dijk M, Broer L, van den Berg MH, Laven JSE, van Leeuwen FE, Lambalk CB, Overbeek A, Loonen JJ, van der Pal HJ, Tissing WJ, Versluys B, Bresters D, Beerendonk CCM, Ronckers CR, van der Heiden-van der Loo M, Kaspers GL, de Vries ACH, Robison LL, Hudson MM, Chemaitilly W, Byrne J, Berger C, Clemens E, Dirksen U, Winther JF, Fosså SD, Grabow D, Haupt R, Kaiser M, Kepak T, Kruseova J, Modan-Moses D, Pluijm SMF, Spix C, Zolk O, Kaatsch P, Krijthe JH, Kremer LC, Yasui Y, Brooke RJ, Uitterlinden AG, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E. van der Kooi ALF, et al. Hum Reprod. 2021 Mar 18;36(4):1120-1133. doi: 10.1093/humrep/deaa342. Hum Reprod. 2021. PMID: 33582778 Free PMC article.
STUDY QUESTION: Do genetic variations in the DNA damage response pathway modify the adverse effect of alkylating agents on ovarian function in female childhood cancer survivors (CCS)? SUMMARY ANSWER: Female CCS carrying a common BR serine/threonine kinase 1 (BRSK1) …
STUDY QUESTION: Do genetic variations in the DNA damage response pathway modify the adverse effect of alkylating agents on ovarian function …
Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.
Wang H, Liu XB, Chen JH, Wang QQ, Chen JP, Xu JF, Sheng CY, Ni QC. Wang H, et al. Exp Mol Pathol. 2014 Oct;97(2):191-201. doi: 10.1016/j.yexmp.2014.07.012. Epub 2014 Jul 16. Exp Mol Pathol. 2014. PMID: 25036402
The objective of this study was to examine the effect of brain specific kinase 1 (BRSK1) expression on Jab1 over-expression and related signaling pathway in breast cancer. ...Kaplan-Meier analysis revealed that survival curves of low versus high expressers of cytopl …
The objective of this study was to examine the effect of brain specific kinase 1 (BRSK1) expression on Jab1 over-expression and relat …
Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers.
Choi EJ, Yoo NJ, Kim MS, An CH, Lee SH. Choi EJ, et al. Oncology. 2016;91(5):289-294. doi: 10.1159/000450616. Epub 2016 Sep 28. Oncology. 2016. PMID: 27677186
OBJECTIVE: The transcription factor-encoding EGR1 and the kinase-encoding BRSK1 are considered putative tumor suppressor genes (TSGs). However, EGR1 and BRSK1 mutations that could inactivate their functions are not reported in colorectal (CRC) and gastric (GC) ca …
OBJECTIVE: The transcription factor-encoding EGR1 and the kinase-encoding BRSK1 are considered putative tumor suppressor genes (TSGs) …
Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment.
Nguyen K, Rivera A, Alzoubi M, Wathieu H, Dong S, Yousefi H, Matossian M, Alahari S, Drewry D, Burow M, Collins-Burow B. Nguyen K, et al. Oncotarget. 2021 May 25;12(11):1110-1115. doi: 10.18632/oncotarget.27929. eCollection 2021 May 25. Oncotarget. 2021. PMID: 34084284 Free PMC article. Review.
LKB1-signaling has prominent roles in cancer development and metastasis. This report evaluates LKB1-signaling pathway gene expression associations with patient survival in overall breast cancer, specific subtypes, as well as pre- and post-chemotherapy. ...Our findin …
LKB1-signaling has prominent roles in cancer development and metastasis. This report evaluates LKB1-signaling pathway gene expression …
Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors.
Homer MV, Charo LM, Natarajan L, Haunschild C, Chung K, Mao JJ, DeMichele AM, Su HI. Homer MV, et al. Menopause. 2017 Jun;24(6):663-668. doi: 10.1097/GME.0000000000000817. Menopause. 2017. PMID: 28118297 Free PMC article.
OBJECTIVE: To determine if interindividual genetic variation in single-nucleotide polymorphisms (SNPs) related to age at natural menopause is associated with risk of ovarian failure in breast cancer survivors. METHODS: A prospective cohort of 169 premenopausal breast ca …
OBJECTIVE: To determine if interindividual genetic variation in single-nucleotide polymorphisms (SNPs) related to age at natural menopause i …
Using random walks to identify cancer-associated modules in expression data.
Petrochilos D, Shojaie A, Gennari J, Abernethy N. Petrochilos D, et al. BioData Min. 2013 Oct 15;6(1):17. doi: 10.1186/1756-0381-6-17. BioData Min. 2013. PMID: 24128261 Free PMC article.
To better represent and study the intricate genetics of cancer onset and progression, we construct a network of biological interactions to search for groups of genes that compose cancer-related modules. Three cancer expression datasets are investigated to pri …
To better represent and study the intricate genetics of cancer onset and progression, we construct a network of biological interactio …
22 results