Bach P - Search Results

1

Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.

Bach P, Knerr L, Fjellström O, Hansson K, Mattsson C, Gustafsson D. Bach P, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):821-7. doi: 10.1016/j.bmcl.2013.12.094. Epub 2013 Dec 29. Bioorg Med Chem Lett. 2014. PMID: 24418773

2

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.

Bach P, Boström J, Brickmann K, van Giezen JJ, Hovland R, Petersson AU, Ray A, Zetterberg F. Bach P, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):2877-81. doi: 10.1016/j.bmcl.2011.03.088. Epub 2011 Mar 30. Bioorg Med Chem Lett. 2011. PMID: 21507636

3

A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).

Bach P, Nilsson K, Wållberg A, Bauer U, Hammerland LG, Peterson A, Svensson T, Osterlund K, Karis D, Boije M, Wensbo D. Bach P, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. doi: 10.1016/j.bmcl.2006.06.079. Epub 2006 Jul 12. Bioorg Med Chem Lett. 2006. PMID: 16839764

4

Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).

Bach P, Nilsson K, Svensson T, Bauer U, Hammerland LG, Peterson A, Wållberg A, Osterlund K, Karis D, Boije M, Wensbo D. Bach P, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. doi: 10.1016/j.bmcl.2006.06.078. Epub 2006 Jul 11. Bioorg Med Chem Lett. 2006. PMID: 16837196

5

Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations.

Giordanetto F, Bach P, Zetterberg F, Antonsson T, Bylund R, Johansson J, Sellén M, Brown D, Hideståhl L, Berntsson P, Hovdal D, Zachrisson H, Björkman JA, van Giezen JJ. Giordanetto F, et al. Among authors: bach p. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2963-8. doi: 10.1016/j.bmcl.2014.04.001. Epub 2014 Apr 12. Bioorg Med Chem Lett. 2014. PMID: 24835983

6

Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y₁₂ receptor.

Bach P, Boström J, Brickmann K, van Giezen JJ, Groneberg RD, Harvey DM, O'Sullivan M, Zetterberg F. Bach P, et al. Eur J Med Chem. 2013 Jul;65:360-75. doi: 10.1016/j.ejmech.2013.04.007. Epub 2013 May 15. Eur J Med Chem. 2013. PMID: 23747805

7

5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.

Bach P, Boström J, Brickmann K, Burgess LE, Clarke D, Groneberg RD, Harvey DM, Laird ER, O'Sullivan M, Zetterberg F. Bach P, et al. Future Med Chem. 2013 Nov;5(17):2037-56. doi: 10.4155/fmc.13.171. Future Med Chem. 2013. PMID: 24215345

8

Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.

Bach P, Antonsson T, Bylund R, Björkman JA, Österlund K, Giordanetto F, van Giezen JJ, Andersen SM, Zachrisson H, Zetterberg F. Bach P, et al. J Med Chem. 2013 Sep 12;56(17):7015-24. doi: 10.1021/jm400820m. Epub 2013 Aug 29. J Med Chem. 2013. PMID: 23899349

9

What is the ideal time to begin tapering opioid agonist treatment? A protocol for a retrospective population-based comparative effectiveness study in British Columbia, Canada.

Yan R, Kurz M, Guerra-Alejos BC, Min JE, Bach P, Greenland S, Gustafson P, Karim E, Korthuis PT, Loughin T, McCandless L, Platt RW, Schnepel K, Seaman S, Socías ME, Wood E, Xie H, Nosyk B. Yan R, et al. Among authors: bach p. BMJ Open. 2024 Apr 29;14(4):e083453. doi: 10.1136/bmjopen-2023-083453. BMJ Open. 2024. PMID: 38684262

10

Side effects of drug-antibody conjugates enfortumab-vedotin and sacituzumab-govitecan in targeted therapy in cancer.

Reike MJ, Bahlburg H, Brehmer M, Berg S, Noldus J, Roghmann F, Bach P, Tully KH. Reike MJ, et al. Among authors: bach p. Cancer Epidemiol. 2024 Apr 23;90:102574. doi: 10.1016/j.canep.2024.102574. Online ahead of print. Cancer Epidemiol. 2024. PMID: 38657392

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