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Activation of the CARD8 Inflammasome Requires a Disordered Region.
Chui AJ, Griswold AR, Taabazuing CY, Orth EL, Gai K, Rao SD, Ball DP, Hsiao JC, Bachovchin DA. Chui AJ, et al. Among authors: bachovchin da. Cell Rep. 2020 Oct 13;33(2):108264. doi: 10.1016/j.celrep.2020.108264. Cell Rep. 2020. PMID: 33053349 Free PMC article.
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
Okondo MC, Johnson DC, Sridharan R, Go EB, Chui AJ, Wang MS, Poplawski SE, Wu W, Liu Y, Lai JH, Sanford DG, Arciprete MO, Golub TR, Bachovchin WW, Bachovchin DA. Okondo MC, et al. Among authors: bachovchin da, bachovchin ww. Nat Chem Biol. 2017 Jan;13(1):46-53. doi: 10.1038/nchembio.2229. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820798 Free PMC article.
Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.
Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Okondo MC, et al. Among authors: bachovchin da. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. Cell Chem Biol. 2018. PMID: 29396289 Free PMC article.
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA. Johnson DC, et al. Among authors: bachovchin da. Nat Med. 2018 Aug;24(8):1151-1156. doi: 10.1038/s41591-018-0082-y. Epub 2018 Jul 2. Nat Med. 2018. PMID: 29967349 Free PMC article.
N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA. Chui AJ, et al. Among authors: bachovchin da. Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14. Science. 2019. PMID: 30872531 Free PMC article.
A Chemical Strategy for Protease Substrate Profiling.
Griswold AR, Cifani P, Rao SD, Axelrod AJ, Miele MM, Hendrickson RC, Kentsis A, Bachovchin DA. Griswold AR, et al. Among authors: bachovchin da. Cell Chem Biol. 2019 Jun 20;26(6):901-907.e6. doi: 10.1016/j.chembiol.2019.03.007. Epub 2019 Apr 18. Cell Chem Biol. 2019. PMID: 31006619 Free PMC article.
Caspase-1 interdomain linker cleavage is required for pyroptosis.
Ball DP, Taabazuing CY, Griswold AR, Orth EL, Rao SD, Kotliar IB, Vostal LE, Johnson DC, Bachovchin DA. Ball DP, et al. Among authors: bachovchin da. Life Sci Alliance. 2020 Feb 12;3(3):e202000664. doi: 10.26508/lsa.202000664. Print 2020 Mar. Life Sci Alliance. 2020. PMID: 32051255 Free PMC article.
61 results