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Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Asahi M, Otsu K, Nakayama H, Hikoso S, Takeda T, Gramolini AO, Trivieri MG, Oudit GY, Morita T, Kusakari Y, Hirano S, Hongo K, Hirotani S, Yamaguchi O, Peterson A, Backx PH, Kurihara S, Hori M, MacLennan DH. Asahi M, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204. doi: 10.1073/pnas.0402596101. Epub 2004 Jun 16. Proc Natl Acad Sci U S A. 2004. PMID: 15201433 Free PMC article.
Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.
Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH. Gramolini AO, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2446-51. doi: 10.1073/pnas.0510883103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461894 Free PMC article.
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.
Trivieri MG, Oudit GY, Sah R, Kerfant BG, Sun H, Gramolini AO, Pan Y, Wickenden AD, Croteau W, Morreale de Escobar G, Pekhletski R, St Germain D, Maclennan DH, Backx PH. Trivieri MG, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6043-8. doi: 10.1073/pnas.0601072103. Epub 2006 Apr 4. Proc Natl Acad Sci U S A. 2006. PMID: 16595628 Free PMC article.
Tbx5-dependent pathway regulating diastolic function in congenital heart disease.
Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. Zhu Y, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5519-24. doi: 10.1073/pnas.0801779105. Epub 2008 Mar 31. Proc Natl Acad Sci U S A. 2008. PMID: 18378906 Free PMC article.
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO. Bousette N, et al. Among authors: backx ph. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. doi: 10.1073/pnas.1013555107. Epub 2010 Oct 11. Proc Natl Acad Sci U S A. 2010. PMID: 20937869 Free PMC article.
Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.
Tupling AR, Bombardier E, Gupta SC, Hussain D, Vigna C, Bloemberg D, Quadrilatero J, Trivieri MG, Babu GJ, Backx PH, Periasamy M, MacLennan DH, Gramolini AO. Tupling AR, et al. Among authors: backx ph. Am J Physiol Cell Physiol. 2011 Oct;301(4):C841-9. doi: 10.1152/ajpcell.00409.2010. Epub 2011 Jun 22. Am J Physiol Cell Physiol. 2011. PMID: 21697544 Free PMC article.
226 results