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Page 1
Ginkgo biloba: indications, mechanisms, and safety.
Diamond BJ, Bailey MR. Diamond BJ, et al. Psychiatr Clin North Am. 2013 Mar;36(1):73-83. doi: 10.1016/j.psc.2012.12.006. Psychiatr Clin North Am. 2013. PMID: 23538078 Review.
Mechanisms of action include increasing cerebral blood flow, antioxidant and antiinflammatory effects, with antiplatelet effects attributed to flavone and terpene lactones. Possible interactions with monoamine oxidase inhibitors, alprazolam, haloperidol, warfarin, and nife …
Mechanisms of action include increasing cerebral blood flow, antioxidant and antiinflammatory effects, with antiplatelet effects attributed …
Natural products and adverse drug interactions.
Bailey DG, Dresser GK. Bailey DG, et al. CMAJ. 2004 May 11;170(10):1531-2. doi: 10.1503/cmaj.1031558. CMAJ. 2004. PMID: 15136542 Free PMC article. No abstract available.
Coffee-Antihypertensive Drug Interaction: A Hemodynamic and Pharmacokinetic Study With Felodipine.
Bailey DG, Dresser GK, Urquhart BL, Freeman DJ, Arnold JM. Bailey DG, et al. Am J Hypertens. 2016 Dec 1;29(12):1386-1393. doi: 10.1093/ajh/hpw081. Am J Hypertens. 2016. PMID: 27481881 Clinical Trial.
Plasma felodipine concentration-diastolic blood pressure reduction relationship shifted with coffee such that doubling the felodipine concentration would eliminate the pressor effect. However, this may increase the risk of adverse drug events particularly during the …
Plasma felodipine concentration-diastolic blood pressure reduction relationship shifted with coffee such that doubling the felodipine concen …
A basic conceptual and practical overview of interactions with highly prescribed drugs.
Dresser GK, Bailey DG. Dresser GK, et al. Can J Clin Pharmacol. 2002 Winter;9(4):191-8. Can J Clin Pharmacol. 2002. PMID: 12584577 Review.
Drug interactions are frequently the result of altered activity of the mechanism(s) responsible for drug elimination. ...Adverse drug interactions can result from induction (loss of therapeutic benefit) or inhibition (increased toxicity f …
Drug interactions are frequently the result of altered activity of the mechanism(s) responsible for drug elimination. . …
Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices.
Pepin XJH, Moir AJ, Mann JC, Sanderson NJ, Barker R, Meehan E, Plumb AP, Bailey GR, Murphy DS, Krejsa CM, Andrew MA, Ingallinera TG, Slatter JG. Pepin XJH, et al. Eur J Pharm Biopharm. 2019 Sep;142:435-448. doi: 10.1016/j.ejpb.2019.07.011. Epub 2019 Jul 12. Eur J Pharm Biopharm. 2019. PMID: 31306750
Acalabrutinib is a substrate of PgP and CYP3A4, with a significant fraction of drug metabolized by first pass gut extraction and 25% absolute bioavailability. ...P-PSD values obtained for various batches of acalabrutinib products in simple buffers, or in complex flu …
Acalabrutinib is a substrate of PgP and CYP3A4, with a significant fraction of drug metabolized by first pass gut extraction and 25% …