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N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.
Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Bailey-Downs LC. Gangjee A, et al. Among authors: bailey downs lc. Bioorg Med Chem. 2013 Mar 1;21(5):1312-23. doi: 10.1016/j.bmc.2012.12.045. Epub 2013 Jan 10. Bioorg Med Chem. 2013. PMID: 23375090 Free PMC article.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: bailey downs lc. Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14. Bioorg Med Chem. 2014. PMID: 24890652 Free PMC article.
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA. Bastian A, et al. Among authors: bailey downs lc. J Pharmacol Exp Ther. 2015 May;353(2):392-404. doi: 10.1124/jpet.114.220335. Epub 2015 Feb 26. J Pharmacol Exp Ther. 2015. PMID: 25720766 Free PMC article.
Identification of novel drugs to target dormant micrometastases.
Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Hurst RE, et al. Among authors: bailey downs lc. BMC Cancer. 2015 May 14;15:404. doi: 10.1186/s12885-015-1409-4. BMC Cancer. 2015. PMID: 25971923 Free PMC article.
AG488 as a therapy against gliomas.
Ziegler J, Bastian A, Lerner M, Bailey-Downs L, Saunders D, Smith N, Sutton J, Battiste JD, Ihnat MA, Gangjee A, Towner RA. Ziegler J, et al. Oncotarget. 2017 May 30;8(42):71833-71844. doi: 10.18632/oncotarget.18284. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069750 Free PMC article.
20 results