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A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.
Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, Garaffo G, Vernersson-Lindahl E, Merlo G, Mills AA, Ballarò C, Alemà S, Chimenti S, Guerrini L, Costanzo A. Moretti F, et al. Among authors: ballaro c. J Clin Invest. 2010 May;120(5):1570-7. doi: 10.1172/JCI40267. Epub 2010 Apr 26. J Clin Invest. 2010. PMID: 20424325 Free PMC article.
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. Marinari B, et al. Among authors: ballaro c. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17091-6. doi: 10.1073/pnas.0809288105. Epub 2008 Oct 28. Proc Natl Acad Sci U S A. 2008. PMID: 18957551 Free PMC article.