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Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.
Lisco A, Vanpouille C, Tchesnokov EP, Grivel JC, Biancotto A, Brichacek B, Elliott J, Fromentin E, Shattock R, Anton P, Gorelick R, Balzarini J, McGuigan C, Derudas M, Götte M, Schinazi RF, Margolis L. Lisco A, et al. Among authors: balzarini j. Cell Host Microbe. 2008 Sep 11;4(3):260-270. doi: 10.1016/j.chom.2008.07.008. Cell Host Microbe. 2008. PMID: 18779052 Free PMC article.
Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
McGuigan C, Derudas M, Bugert JJ, Andrei G, Snoeck R, Balzarini J. McGuigan C, et al. Among authors: balzarini j. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4364-7. doi: 10.1016/j.bmcl.2008.06.069. Epub 2008 Jun 24. Bioorg Med Chem Lett. 2008. PMID: 18614365
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin.
Vanpouille C, Lisco A, Introini A, Grivel JC, Munawwar A, Merbah M, Schinazi RF, Derudas M, McGuigan C, Balzarini J, Margolis L. Vanpouille C, et al. Among authors: balzarini j. Antimicrob Agents Chemother. 2012 May;56(5):2604-11. doi: 10.1128/AAC.05986-11. Epub 2012 Feb 6. Antimicrob Agents Chemother. 2012. PMID: 22314523 Free PMC article.
Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.
Derudas M, Vanpouille C, Carta D, Zicari S, Andrei G, Snoeck R, Brancale A, Margolis L, Balzarini J, McGuigan C. Derudas M, et al. Among authors: balzarini j. J Med Chem. 2017 Sep 28;60(18):7876-7896. doi: 10.1021/acs.jmedchem.7b01009. Epub 2017 Sep 19. J Med Chem. 2017. PMID: 28829913 Free PMC article.
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.
Vanpouille C, Lisco A, Derudas M, Saba E, Grivel JC, Brichacek B, Scrimieri F, Schinazi R, Schols D, McGuigan C, Balzarini J, Margolis L. Vanpouille C, et al. Among authors: balzarini j. J Infect Dis. 2010 Feb 15;201(4):635-43. doi: 10.1086/650343. J Infect Dis. 2010. PMID: 20085496 Free PMC article.
Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.
McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, Madela K, Meneghesso S, Pertusati F, Serpi M, Slusarczyk M, Chamberlain S, Kolykhalov A, Vernachio J, Vanpouille C, Introini A, Margolis L, Balzarini J. McGuigan C, et al. Among authors: balzarini j. Eur J Med Chem. 2013;70:326-40. doi: 10.1016/j.ejmech.2013.09.047. Epub 2013 Oct 9. Eur J Med Chem. 2013. PMID: 24177359 Free PMC article.
1,242 results