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RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies.
Harfouche C, Filippini S, Gianfaldoni C, Ruggiero P, Moschioni M, Maccari S, Pancotto L, Arcidiacono L, Galletti B, Censini S, Mori E, Giuliani M, Facciotti C, Cartocci E, Savino S, Doro F, Pallaoro M, Nocadello S, Mancuso G, Haston M, Goldblatt D, Barocchi MA, Pizza M, Rappuoli R, Masignani V. Harfouche C, et al. Among authors: barocchi ma. Infect Immun. 2012 Jan;80(1):451-60. doi: 10.1128/IAI.05780-11. Epub 2011 Nov 14. Infect Immun. 2012. PMID: 22083702 Free PMC article.
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
Gianfaldoni C, Censini S, Hilleringmann M, Moschioni M, Facciotti C, Pansegrau W, Masignani V, Covacci A, Rappuoli R, Barocchi MA, Ruggiero P. Gianfaldoni C, et al. Among authors: barocchi ma. Infect Immun. 2007 Feb;75(2):1059-62. doi: 10.1128/IAI.01400-06. Epub 2006 Dec 4. Infect Immun. 2007. PMID: 17145945 Free PMC article.
The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo.
Moschioni M, Emolo C, Biagini M, Maccari S, Pansegrau W, Donati C, Hilleringmann M, Ferlenghi I, Ruggiero P, Sinisi A, Pizza M, Norais N, Barocchi MA, Masignani V. Moschioni M, et al. Among authors: barocchi ma. Infect Immun. 2010 Dec;78(12):5033-42. doi: 10.1128/IAI.00601-10. Epub 2010 Sep 7. Infect Immun. 2010. PMID: 20823200 Free PMC article.
A pneumococcal pilus influences virulence and host inflammatory responses.
Barocchi MA, Ries J, Zogaj X, Hemsley C, Albiger B, Kanth A, Dahlberg S, Fernebro J, Moschioni M, Masignani V, Hultenby K, Taddei AR, Beiter K, Wartha F, von Euler A, Covacci A, Holden DW, Normark S, Rappuoli R, Henriques-Normark B. Barocchi MA, et al. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2857-62. doi: 10.1073/pnas.0511017103. Epub 2006 Feb 15. Proc Natl Acad Sci U S A. 2006. PMID: 16481624 Free PMC article.
35 results