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The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. Popik P, et al. Among authors: basile as. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. doi: 10.1124/jpet.106.107201. Epub 2006 Sep 13. J Pharmacol Exp Ther. 2006. PMID: 16971504
Triple reuptake inhibitors ("broad spectrum" antidepressants).
Skolnick P, Basile AS. Skolnick P, et al. Among authors: basile as. CNS Neurol Disord Drug Targets. 2007 Apr;6(2):141-9. doi: 10.2174/187152707780363285. CNS Neurol Disord Drug Targets. 2007. PMID: 17430151 Review.
Effects of the triple monoamine uptake inhibitor DOV 102,677 on alcohol-motivated responding and antidepressant activity in alcohol-preferring (P) rats.
Yang AR, Yi HS, Warnock KT, Mamczarz J, June HL Jr, Mallick N, Krieter PA, Tonelli L, Skolnick P, Basile AS, June HL Sr. Yang AR, et al. Among authors: basile as. Alcohol Clin Exp Res. 2012 May;36(5):863-73. doi: 10.1111/j.1530-0277.2011.01671.x. Epub 2011 Dec 7. Alcohol Clin Exp Res. 2012. PMID: 22150508 Free PMC article.
The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.
Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS. Tizzano JP, et al. Among authors: basile as. J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. doi: 10.1124/jpet.107.133132. Epub 2007 Dec 18. J Pharmacol Exp Ther. 2008. PMID: 18089843
Preclinical evaluation of the abuse potential of the analgesic bicifadine.
Nicholson KL, Balster RL, Golembiowska K, Kowalska M, Tizzano JP, Skolnick P, Basile AS. Nicholson KL, et al. Among authors: basile as. J Pharmacol Exp Ther. 2009 Jul;330(1):236-48. doi: 10.1124/jpet.109.150540. Epub 2009 Apr 8. J Pharmacol Exp Ther. 2009. PMID: 19357320 Free PMC article.
Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.
Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Berezhnoy D, et al. Among authors: basile as. BMC Pharmacol. 2008 Jun 13;8:11. doi: 10.1186/1471-2210-8-11. BMC Pharmacol. 2008. PMID: 18554397 Free PMC article.
142 results