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Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.
Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey B, Radford SE, Jat PS, Collinge J, Bieschke J. Nahass GR, et al. Among authors: batchelor m. J Mol Biol. 2021 Apr 16;433(8):166878. doi: 10.1016/j.jmb.2021.166878. Epub 2021 Feb 19. J Mol Biol. 2021. PMID: 33610557 Free PMC article.
The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.
Hosszu LL, Jackson GS, Trevitt CR, Jones S, Batchelor M, Bhelt D, Prodromidou K, Clarke AR, Waltho JP, Collinge J. Hosszu LL, et al. Among authors: batchelor m. J Biol Chem. 2004 Jul 2;279(27):28515-21. doi: 10.1074/jbc.M313762200. Epub 2004 Apr 27. J Biol Chem. 2004. PMID: 15123682 Free article.
Recombinant prion protein does not possess SOD-1 activity.
Jones S, Batchelor M, Bhelt D, Clarke AR, Collinge J, Jackson GS. Jones S, et al. Among authors: batchelor m. Biochem J. 2005 Dec 1;392(Pt 2):309-12. doi: 10.1042/BJ20051236. Biochem J. 2005. PMID: 16156720 Free PMC article.
Definable equilibrium states in the folding of human prion protein.
Hosszu LL, Wells MA, Jackson GS, Jones S, Batchelor M, Clarke AR, Craven CJ, Waltho JP, Collinge J. Hosszu LL, et al. Among authors: batchelor m. Biochemistry. 2005 Dec 20;44(50):16649-57. doi: 10.1021/bi051277k. Biochemistry. 2005. PMID: 16342955
Conformational properties of beta-PrP.
Hosszu LLP, Trevitt CR, Jones S, Batchelor M, Scott DJ, Jackson GS, Collinge J, Waltho JP, Clarke AR. Hosszu LLP, et al. Among authors: batchelor m. J Biol Chem. 2009 Aug 14;284(33):21981-21990. doi: 10.1074/jbc.M809173200. Epub 2009 Apr 15. J Biol Chem. 2009. PMID: 19369250 Free PMC article.
N-terminal domain of prion protein directs its oligomeric association.
Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR. Trevitt CR, et al. Among authors: batchelor m. J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074940 Free PMC article.
A systematic investigation of production of synthetic prions from recombinant prion protein.
Schmidt C, Fizet J, Properzi F, Batchelor M, Sandberg MK, Edgeworth JA, Afran L, Ho S, Badhan A, Klier S, Linehan JM, Brandner S, Hosszu LL, Tattum MH, Jat P, Clarke AR, Klöhn PC, Wadsworth JD, Jackson GS, Collinge J. Schmidt C, et al. Among authors: batchelor m. Open Biol. 2015 Dec;5(12):150165. doi: 10.1098/rsob.150165. Open Biol. 2015. PMID: 26631378 Free PMC article.
Structural effects of the highly protective V127 polymorphism on human prion protein.
Hosszu LLP, Conners R, Sangar D, Batchelor M, Sawyer EB, Fisher S, Cliff MJ, Hounslow AM, McAuley K, Leo Brady R, Jackson GS, Bieschke J, Waltho JP, Collinge J. Hosszu LLP, et al. Among authors: batchelor m. Commun Biol. 2020 Jul 29;3(1):402. doi: 10.1038/s42003-020-01126-6. Commun Biol. 2020. PMID: 32728168 Free PMC article.
122 results