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Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and X-ray crystallographic studies.
Couturier C, Silve S, Morales R, Pessegue B, Llopart S, Nair A, Bauer A, Scheiper B, Pöverlein C, Ganzhorn A, Lagrange S, Bacqué E. Couturier C, et al. Among authors: bauer a. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1455-9. doi: 10.1016/j.bmcl.2015.02.035. Epub 2015 Feb 23. Bioorg Med Chem Lett. 2015. PMID: 25770781
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.
Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: bauer a. J Med Chem. 2005 Jul 14;48(14):4511-25. doi: 10.1021/jm0490540. J Med Chem. 2005. PMID: 15999990
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.
Kling A, Lukat P, Almeida DV, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel SC, König C, Ammerman NC, Barrio MB, Borchers K, Bordon-Pallier F, Brönstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz DW, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset JH, Lagrange S, Müller R. Kling A, et al. Among authors: bauer a. Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690. Science. 2015. PMID: 26045430
Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.
Degiacomi G, Personne Y, Mondésert G, Ge X, Mandava CS, Hartkoorn RC, Boldrin F, Goel P, Peisker K, Benjak A, Barrio MB, Ventura M, Brown AC, Leblanc V, Bauer A, Sanyal S, Cole ST, Lagrange S, Parish T, Manganelli R. Degiacomi G, et al. Among authors: bauer a. Tuberculosis (Edinb). 2016 Sep;100:95-101. doi: 10.1016/j.tube.2016.07.011. Epub 2016 Jul 27. Tuberculosis (Edinb). 2016. PMID: 27553416
Identification and optimization of a new series of anti-tubercular quinazolinones.
Couturier C, Lair C, Pellet A, Upton A, Kaneko T, Perron C, Cogo E, Menegotto J, Bauer A, Scheiper B, Lagrange S, Bacqué E. Couturier C, et al. Among authors: bauer a. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5290-5299. doi: 10.1016/j.bmcl.2016.09.043. Epub 2016 Sep 16. Bioorg Med Chem Lett. 2016. PMID: 27671498
2,959 results