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Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
Dgachi Y, Ismaili L, Knez D, Benchekroun M, Martin H, Szałaj N, Wehle S, Bautista-Aguilera OM, Luzet V, Bonnet A, Malawska B, Gobec S, Chioua M, Decker M, Chabchoub F, Marco-Contelles J. Dgachi Y, et al. ChemMedChem. 2016 Jun 20;11(12):1318-27. doi: 10.1002/cmdc.201500539. Epub 2016 Jan 25. ChemMedChem. 2016. PMID: 26804623
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Bautista-Aguilera OM, Esteban G, Bolea I, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Samadi A, Soriano E, Unzeta M, Marco-Contelles J. Bautista-Aguilera OM, et al. Eur J Med Chem. 2014 Mar 21;75:82-95. doi: 10.1016/j.ejmech.2013.12.028. Epub 2014 Jan 27. Eur J Med Chem. 2014. PMID: 24530494
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Wang L, Esteban G, Ojima M, Bautista-Aguilera OM, Inokuchi T, Moraleda I, Iriepa I, Samadi A, Youdim MB, Romero A, Soriano E, Herrero R, Fernández Fernández AP, Ricardo-Martínez-Murillo, Marco-Contelles J, Unzeta M. Wang L, et al. Eur J Med Chem. 2014 Jun 10;80:543-61. doi: 10.1016/j.ejmech.2014.04.078. Epub 2014 Apr 29. Eur J Med Chem. 2014. PMID: 24813882
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J. Bautista-Aguilera OM, et al. Drug Des Devel Ther. 2014 Oct 13;8:1893-910. doi: 10.2147/DDDT.S69258. eCollection 2014. Drug Des Devel Ther. 2014. PMID: 25378907 Free PMC article.
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
Bautista-Aguilera OM, Samadi A, Chioua M, Nikolic K, Filipic S, Agbaba D, Soriano E, de Andrés L, Rodríguez-Franco MI, Alcaro S, Ramsay RR, Ortuso F, Yañez M, Marco-Contelles J. Bautista-Aguilera OM, et al. J Med Chem. 2014 Dec 26;57(24):10455-63. doi: 10.1021/jm501501a. Epub 2014 Dec 8. J Med Chem. 2014. PMID: 25418133
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Dgachi Y, Bautista-Aguilera OM, Benchekroun M, Martin H, Bonet A, Knez D, Godyń J, Malawska B, Gobec S, Chioua M, Janockova J, Soukup O, Chabchoub F, Marco-Contelles J, Ismaili L. Dgachi Y, et al. Molecules. 2016 May 14;21(5):634. doi: 10.3390/molecules21050634. Molecules. 2016. PMID: 27187348 Free PMC article.
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.
Criado M, Mulet J, Sala F, Sala S, Colmena I, Gandía L, Bautista-Aguilera OM, Samadi A, Chioua M, Marco-Contelles J. Criado M, et al. ACS Chem Neurosci. 2016 Aug 17;7(8):1157-65. doi: 10.1021/acschemneuro.6b00122. Epub 2016 Jun 10. ACS Chem Neurosci. 2016. PMID: 27254782 Free article.
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
Benchekroun M, Romero A, Egea J, León R, Michalska P, Buendía I, Jimeno ML, Jun D, Janockova J, Sepsova V, Soukup O, Bautista-Aguilera OM, Refouvelet B, Ouari O, Marco-Contelles J, Ismaili L. Benchekroun M, et al. Among authors: bautista aguilera om. J Med Chem. 2016 Nov 10;59(21):9967-9973. doi: 10.1021/acs.jmedchem.6b01178. Epub 2016 Oct 31. J Med Chem. 2016. PMID: 27736061
19 results