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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
2001 1
2002 1
2003 12
2004 14
2005 33
2006 38
2007 44
2008 50
2009 55
2010 62
2011 81
2012 70
2013 73
2014 74
2015 60
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2017 68
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2023 25
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944 results

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Page 1
Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos.
Anderson FL, von Herrmann KM, Young AL, Havrda MC. Anderson FL, et al. Toxicol Sci. 2021 Sep 28;183(2):378-392. doi: 10.1093/toxsci/kfab090. Toxicol Sci. 2021. PMID: 34289071 Free PMC article.
CPF exposure altered the expression of genes associated with intrinsic apoptosis, significantly elevating expression of the pro-apoptotic mediator Bbc3/Puma. Bbc3 loss attenuated CPF driven neurotoxicity, induction of other intrinsic apoptosis regulatory genes inclu …
CPF exposure altered the expression of genes associated with intrinsic apoptosis, significantly elevating expression of the pro-apoptotic me …
BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.
Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J, Liao H. Liu H, et al. Cell Death Dis. 2017 Mar 9;8(3):e2657. doi: 10.1038/cddis.2017.78. Cell Death Dis. 2017. PMID: 28277537 Free PMC article.
Here, we exposed U937 cell-derived macrophages (UDMs) to SiO(2) in vitro to explore the function of BBC3 in SiO(2)-induced disease. We found that SiO(2) induced increased BBC3 expression, as well as macrophage activation and apoptosis. Knockdown of Bbc3 with …
Here, we exposed U937 cell-derived macrophages (UDMs) to SiO(2) in vitro to explore the function of BBC3 in SiO(2)-induced disease. W …
Diosgenin increases BBC3 expression in HepG2/C3A cells and alters cell communication in a 3D spheroid model.
da Silva MF, de Lima LVA, Zanetti TA, Felicidade I, Favaron PO, Lepri SR, Lirio Rondina DB, Mantovani MS. da Silva MF, et al. Mutat Res Genet Toxicol Environ Mutagen. 2022 Jul-Aug;879-880:503512. doi: 10.1016/j.mrgentox.2022.503512. Epub 2022 Jun 12. Mutat Res Genet Toxicol Environ Mutagen. 2022. PMID: 35914860
Apoptosis was associated with an increase in the expression of BBC3, a participant in the intrinsic apoptosis pathway. Diosgenin also promoted an increase in volume and greater cellular breakdown in spheroids. ...
Apoptosis was associated with an increase in the expression of BBC3, a participant in the intrinsic apoptosis pathway. Diosgenin also …
Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H. Zhang Y, et al. Autophagy. 2016 Sep;12(9):1538-59. doi: 10.1080/15548627.2016.1191723. Epub 2016 Jul 27. Autophagy. 2016. PMID: 27464000 Free PMC article.
BBC3 (BCL2 binding component 3) is a known apoptosis inducer; however, its role in microglial survival remains poorly understood. In addition to the classical transcription factor TRP53, Mir143 is involved in BBC3 expression at the post-transcriptional level. Here, …
BBC3 (BCL2 binding component 3) is a known apoptosis inducer; however, its role in microglial survival remains poorly understood. In …
BBC3 is down-regulated with increased tumor size independently of p53 expression in head and neck cancer.
Tajnik M, Stražišar M, Volavšek M, Boštjančič E, Glavač D. Tajnik M, et al. Cancer Biomark. 2012;11(5):197-208. doi: 10.3233/CBM-2012-00286. Cancer Biomark. 2012. PMID: 23220852
The study focuses on BBC3 gene expression in primary head and neck squamous cell carcinomas (HNSCC) in relation to pTNM classification. ...That suggests the potential use of BBC3 as a new tumor size marker in HNSCC. Through protein expression analysis combined with …
The study focuses on BBC3 gene expression in primary head and neck squamous cell carcinomas (HNSCC) in relation to pTNM classificatio …
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H. Xie W, et al. Autophagy. 2015;11(9):1623-35. doi: 10.1080/15548627.2015.1075688. Autophagy. 2015. PMID: 26212789 Free PMC article.
Inhibition of CMA results in stabilization of BBC3, which in turn sensitizes tumor cells to undergo apoptosis. ...Mechanistically, Ser10 phosphorylation facilitates BBC3 translocation from the cytosol to mitochondria. BBC3 stabilization resulting from either …
Inhibition of CMA results in stabilization of BBC3, which in turn sensitizes tumor cells to undergo apoptosis. ...Mechanistically, Se …
BBC3 mediates fenretinide-induced cell death in neuroblastoma.
Wei JS, Whiteford CC, Cenacchi N, Son CG, Khan J. Wei JS, et al. Oncogene. 2005 Dec 1;24(54):7976-83. doi: 10.1038/sj.onc.1208947. Oncogene. 2005. PMID: 16091745 Free PMC article.
Western analysis confirmed the induction of BBC3 protein by 4-HPR. Furthermore, the induction of BBC3 was associated with the sensitivity to this agent in the cell lines tested. ...Our results indicate that BBC3 mediates cell death in NB cells in response to …
Western analysis confirmed the induction of BBC3 protein by 4-HPR. Furthermore, the induction of BBC3 was associated with the …
A novel compound EPIC-0412 reverses temozolomide resistance via inhibiting DNA repair/MGMT in glioblastoma.
Zhao J, Yang S, Cui X, Wang Q, Yang E, Tong F, Hong B, Xiao M, Xin L, Xu C, Tan Y, Kang C. Zhao J, et al. Neuro Oncol. 2023 May 4;25(5):857-870. doi: 10.1093/neuonc/noac242. Neuro Oncol. 2023. PMID: 36272139 Free PMC article.
RESULTS: EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell cycle arrest and apoptosis in GBM cells. EPIC-0412 inhibits DNA damage response in GBM cells through the p21-E2F1 DNA damage repair axis. . …
RESULTS: EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell …
Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y. Omori K, et al. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1016-26. doi: 10.1152/ajpendo.00441.2015. Epub 2016 Apr 26. Am J Physiol Endocrinol Metab. 2016. PMID: 27117005 Free PMC article.
Cold preservation-mediated islet injury occurred during rewarming in "Firefly" islets. Silencing Bbc3 by transfecting Bbc3 siRNA into islets in vitro prior to cold preservation improved postpreservation mitochondrial viability. ...These results demonstrated the invo …
Cold preservation-mediated islet injury occurred during rewarming in "Firefly" islets. Silencing Bbc3 by transfecting Bbc3 siR …
Knockdown of circHomer1 ameliorates METH-induced neuronal injury through inhibiting Bbc3 expression.
Li J, Sun Q, Zhu S, Xi K, Shi Q, Pang K, Liu X, Li M, Zhang Y, Sun J. Li J, et al. Neurosci Lett. 2020 Jul 27;732:135050. doi: 10.1016/j.neulet.2020.135050. Epub 2020 May 22. Neurosci Lett. 2020. PMID: 32450188
Besides, suppression of Bbc3 decreased the reactive oxygen species (ROS) level and radio of PI-positive cells. Furthermore, we analyzed the correlation in pairs among circHomer1, Bbc3 and behaviors in well-developed METH-addicted models using Pearson's correlation c …
Besides, suppression of Bbc3 decreased the reactive oxygen species (ROS) level and radio of PI-positive cells. Furthermore, we analyz …
944 results