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A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model.
Han X, Samieegohar M, Ridder BJ, Wu WW, Randolph A, Tran P, Sheng J, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Strauss DG, Li Z. Han X, et al. Among authors: becker n. J Pharmacol Toxicol Methods. 2020 Sep;105:106890. doi: 10.1016/j.vascn.2020.106890. Epub 2020 Jun 21. J Pharmacol Toxicol Methods. 2020. PMID: 32574700 Free article.
Automated Patch Clamp Analysis of nAChα7 and Na(V)1.7 Channels.
Obergrussberger A, Haarmann C, Rinke I, Becker N, Guinot D, Brueggemann A, Stoelzle-Feix S, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. Curr Protoc Pharmacol. 2014 Jun 16;65:11.13.1-48. doi: 10.1002/0471141755.ph1113s65. Curr Protoc Pharmacol. 2014. PMID: 24934604
Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module.
Obergrussberger A, Brüggemann A, Goetze TA, Rapedius M, Haarmann C, Rinke I, Becker N, Oka T, Ohtsuki A, Stengel T, Vogel M, Steindl J, Mueller M, Stiehler J, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Lab Autom. 2016 Dec;21(6):779-793. doi: 10.1177/2211068215623209. Epub 2015 Dec 23. J Lab Autom. 2016. PMID: 26702021
Mechanisms of acquired long QT syndrome in patients with propionic academia.
Bodi I, Grünert SC, Becker N, Stoelzle-Feix S, Spiekerkoetter U, Zehender M, Bugger H, Bode C, Odening KE. Bodi I, et al. Among authors: becker n. Heart Rhythm. 2016 Jun;13(6):1335-45. doi: 10.1016/j.hrthm.2016.02.003. Epub 2016 Feb 27. Heart Rhythm. 2016. PMID: 26854997
Safety pharmacology studies using EFP and impedance.
Obergrussberger A, Juhasz K, Thomas U, Stölzle-Feix S, Becker N, Dörr L, Beckler M, Bot C, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:223-32. doi: 10.1016/j.vascn.2016.04.006. Epub 2016 Apr 12. J Pharmacol Toxicol Methods. 2016. PMID: 27084108
An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery.
Obergrussberger A, Goetze TA, Brinkwirth N, Becker N, Friis S, Rapedius M, Haarmann C, Rinke-Weiß I, Stölzle-Feix S, Brüggemann A, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. Expert Opin Drug Discov. 2018 Mar;13(3):269-277. doi: 10.1080/17460441.2018.1428555. Epub 2018 Jan 17. Expert Opin Drug Discov. 2018. PMID: 29343120 Review.
A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time.
Goversen B, Becker N, Stoelzle-Feix S, Obergrussberger A, Vos MA, van Veen TAB, Fertig N, de Boer TP. Goversen B, et al. Among authors: becker n. Front Physiol. 2018 Jan 19;8:1094. doi: 10.3389/fphys.2017.01094. eCollection 2017. Front Physiol. 2018. PMID: 29403387 Free PMC article.
1,053 results