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Effect of grapefruit juice on digoxin pharmacokinetics in humans.
Becquemont L, Verstuyft C, Kerb R, Brinkmann U, Lebot M, Jaillon P, Funck-Brentano C. Becquemont L, et al. Clin Pharmacol Ther. 2001 Oct;70(4):311-6. Clin Pharmacol Ther. 2001. PMID: 11673746 Clinical Trial.
METHODS: Twelve healthy volunteers participated in this open randomized crossover study comparing the effect of grapefruit juice consumption (versus water) on the pharmacokinetics of a single oral dose of digoxin (0.5 mg). ...CONCLUSION: The mod …
METHODS: Twelve healthy volunteers participated in this open randomized crossover study comparing the effect of grapefruit …
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Bhardwaj RK, et al. J Pharmacol Exp Ther. 2002 Aug;302(2):645-50. doi: 10.1124/jpet.102.034728. J Pharmacol Exp Ther. 2002. PMID: 12130727
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying drug metabolism and transport and thereby contribute to interindividual variability in drug disposition. ...We therefore investigated the …
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifyi …