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Sirtuins in yeast: phenotypes and tools.
Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Tsuchiyama S, et al. Among authors: bedalov a. Methods Mol Biol. 2013;1077:11-37. doi: 10.1007/978-1-62703-637-5_2. Methods Mol Biol. 2013. PMID: 24014397
Originally discovered as a transcriptional silencing protein, SIR2 was later linked to yeast replicative aging and the rest was history. Sir2p is now known to be a member of a class of protein deacetylases with a unique enzymatic activity coupling the …
Originally discovered as a transcriptional silencing protein, SIR2 was later linked to yeast replicative aging and the rest was histo …
Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.
Newcomb B, Bedalov A. Newcomb B, et al. Among authors: bedalov a. Methods Mol Biol. 2009;548:145-60. doi: 10.1007/978-1-59745-540-4_8. Methods Mol Biol. 2009. PMID: 19521823 Free PMC article.
A multitude of enzymes that modify histones and remodel nucleosomes are required for the formation, maintenance, and propagation of the transcriptionally repressed chromatin state in eukaryotes. ...
A multitude of enzymes that modify histones and remodel nucleosomes are required for the formation, maintenance, and propagation of t
NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae.
Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA. Bedalov A, et al. Mol Cell Biol. 2003 Oct;23(19):7044-54. doi: 10.1128/mcb.23.19.7044-7054.2003. Mol Cell Biol. 2003. PMID: 12972620 Free PMC article.
We describe a critical role of the NAD(+)-dependent deacetylase Hst1p as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis. ...These findings suggest that Hst1p serves as a cellular NAD(+) sensor that monitors and regulates cellular NAD(+) levels …
We describe a critical role of the NAD(+)-dependent deacetylase Hst1p as a sensor of NAD(+) levels and regulator of NAD(+) bio …
Substrate-specific activation of sirtuins by resveratrol.
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Kaeberlein M, et al. Among authors: bedalov a. J Biol Chem. 2005 Apr 29;280(17):17038-45. doi: 10.1074/jbc.M500655200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684413
Resveratrol, a small molecule found in red wine, is reported to slow aging in simple eukaryotes and has been suggested as a potential calorie restriction mimetic. Resveratrol has also been reported to act as a sirtuin activator, and this property has been pro …
Resveratrol, a small molecule found in red wine, is reported to slow aging in simple eukaryotes and has been suggested as a po …
Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.
Posakony J, Hirao M, Bedalov A. Posakony J, et al. Among authors: bedalov a. Comb Chem High Throughput Screen. 2004 Nov;7(7):661-8. doi: 10.2174/1386207043328346. Comb Chem High Throughput Screen. 2004. PMID: 15578928 Review.
Yeast Sir2 is a defining member of a large family of protein deacetylases found in organisms ranging from bacteria to humans. ...However, years of extensive research did generate a large body of knowledge about the cellular roles of Sir2 in yeast long before …
Yeast Sir2 is a defining member of a large family of protein deacetylases found in organisms ranging from bacteria to humans. …
Biology, Chemistry, and Pharmacology of Sirtuins.
Bedalov A, Chowdhury S, Simon JA. Bedalov A, et al. Methods Enzymol. 2016;574:183-211. doi: 10.1016/bs.mie.2016.03.011. Epub 2016 Mar 28. Methods Enzymol. 2016. PMID: 27423863
Based on its initially discovered activity, Sir2 was classified as a histone deacetylase that removes acetyl groups from histones H3 and H4. ...In this chapter, we describe the biological roles, therapeutic areas in which sirtuins may play a role and development of …
Based on its initially discovered activity, Sir2 was classified as a histone deacetylase that removes acetyl groups from histones H3 …
SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences.
Foss EJ, Lao U, Dalrymple E, Adrianse RL, Loe T, Bedalov A. Foss EJ, et al. Among authors: bedalov a. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):552-557. doi: 10.1073/pnas.1614781114. Epub 2017 Jan 3. Proc Natl Acad Sci U S A. 2017. PMID: 28049846 Free PMC article.
We have developed a technique that allows us to explore the dynamics by which genome replication is completed before mitosis. ...
We have developed a technique that allows us to explore the dynamics by which genome replication is completed before mitosis. ...
A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.
Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. Lessing D, et al. Among authors: bedalov a. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14366-14371. doi: 10.1073/pnas.1617597113. Epub 2016 Nov 23. Proc Natl Acad Sci U S A. 2016. PMID: 28182563 Free PMC article.
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.
Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. Kwan EX, et al. Among authors: bedalov a. PLoS Genet. 2013;9(3):e1003329. doi: 10.1371/journal.pgen.1003329. Epub 2013 Mar 7. PLoS Genet. 2013. PMID: 23505383 Free PMC article.
To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL mapped to the rDNA, with the vineyard rDNA conferring …
To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generat …
Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae.
Banfic H, Bedalov A, York JD, Visnjic D. Banfic H, et al. Among authors: bedalov a. J Biol Chem. 2013 Jan 18;288(3):1717-25. doi: 10.1074/jbc.M112.412288. Epub 2012 Nov 24. J Biol Chem. 2013. PMID: 23179856 Free PMC article.
We found an increase in the activity of Plc1 early after release from the block with a concomitant increase in the levels of InsP(7) and InsP(8). ...Analysis of plc1Δ, kcs1Δ, and ddp1Δ yeast mutants further confirmed the role that a Plc1- and Kcs1-mediated increase …
We found an increase in the activity of Plc1 early after release from the block with a concomitant increase in the levels of InsP(7) …
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