Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.
Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A.
Hirao M, et al. Among authors: bedalov a.
J Biol Chem. 2003 Dec 26;278(52):52773-82. doi: 10.1074/jbc.M308966200. Epub 2003 Oct 8.
J Biol Chem. 2003.
PMID: 14534292
Free article.
The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov, A., Gatbonton, T., Irvine, W. P., Gottschling, D. E., and Simon, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 15 …
The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov …