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CARM1 regulates replication fork speed and stress response by stimulating PARP1.
Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. Genois MM, et al. Among authors: bedford mt. Mol Cell. 2021 Feb 18;81(4):784-800.e8. doi: 10.1016/j.molcel.2020.12.010. Epub 2021 Jan 6. Mol Cell. 2021. PMID: 33412112 Free PMC article.
Enzymatic activity is required for the in vivo functions of CARM1.
Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, Bedford MT. Kim D, et al. Among authors: bedford mt. J Biol Chem. 2010 Jan 8;285(2):1147-52. doi: 10.1074/jbc.M109.035865. Epub 2009 Nov 5. J Biol Chem. 2010. PMID: 19897492 Free PMC article.
SPINDOC binds PARP1 to facilitate PARylation.
Yang F, Chen J, Liu B, Gao G, Sebastian M, Jeter C, Shen J, Person MD, Bedford MT. Yang F, et al. Among authors: bedford mt. Nat Commun. 2021 Nov 4;12(1):6362. doi: 10.1038/s41467-021-26588-y. Nat Commun. 2021. PMID: 34737271 Free PMC article.
PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition.
Li Y, Dobrolecki LE, Sallas C, Zhang X, Kerr TD, Bisht D, Wang Y, Awasthi S, Kaundal B, Wu S, Peng W, Mendillo ML, Lu Y, Jeter CR, Peng G, Liu J, Westin SN, Sood AK, Lewis MT, Das J, Yi SS, Bedford MT, McGrail DJ, Sahni N. Li Y, et al. Among authors: bedford mt. Cell Rep Med. 2023 Dec 19;4(12):101326. doi: 10.1016/j.xcrm.2023.101326. Cell Rep Med. 2023. PMID: 38118413 Free PMC article.
217 results