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Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload.
Nagayama T, Hsu S, Zhang M, Koitabashi N, Bedja D, Gabrielson KL, Takimoto E, Kass DA. Nagayama T, et al. Among authors: bedja d. J Am Coll Cardiol. 2009 Jan 13;53(2):207-15. doi: 10.1016/j.jacc.2008.08.069. J Am Coll Cardiol. 2009. PMID: 19130990 Free PMC article.
Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.
Watts VL, Sepulveda FM, Cingolani OH, Ho AS, Niu X, Kim R, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Rameau G, O'Rourke B, Kass DA, Barouch LA. Watts VL, et al. Among authors: bedja d. J Mol Cell Cardiol. 2013 Sep;62:8-17. doi: 10.1016/j.yjmcc.2013.04.025. Epub 2013 May 2. J Mol Cell Cardiol. 2013. PMID: 23643588 Free PMC article.
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA. Moens AL, et al. Among authors: bedja d. Circulation. 2008 May 20;117(20):2626-36. doi: 10.1161/CIRCULATIONAHA.107.737031. Epub 2008 May 12. Circulation. 2008. PMID: 18474817 Free PMC article.
Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.
Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA. Moens AL, et al. Among authors: bedja d. J Mol Cell Cardiol. 2009 Nov;47(5):576-85. doi: 10.1016/j.yjmcc.2009.06.005. Epub 2009 Sep 18. J Mol Cell Cardiol. 2009. PMID: 19766235 Free PMC article.
Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity.
Raju SV, Zheng M, Schuleri KH, Phan AC, Bedja D, Saraiva RM, Yiginer O, Vandegaer K, Gabrielson KL, O'donnell CP, Berkowitz DE, Barouch LA, Hare JM. Raju SV, et al. Among authors: bedja d. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4222-7. doi: 10.1073/pnas.0510460103. Epub 2006 Mar 6. Proc Natl Acad Sci U S A. 2006. PMID: 16537512 Free PMC article.
106 results