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Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects.
Lowe SL, Wong CJ, Witcher J, Gonzales CR, Dickinson GL, Bell RL, Rorick-Kehn L, Weller M, Stoltz RR, Royalty J, Tauscher-Wisniewski S. Lowe SL, et al. Among authors: bell rl. J Clin Pharmacol. 2014 Sep;54(9):968-78. doi: 10.1002/jcph.286. Epub 2014 Mar 26. J Clin Pharmacol. 2014. PMID: 24619932 Clinical Trial.
Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.
Naganawa M, Dickinson GL, Zheng MQ, Henry S, Vandenhende F, Witcher J, Bell R, Nabulsi N, Lin SF, Ropchan J, Neumeister A, Ranganathan M, Tauscher J, Huang Y, Carson RE. Naganawa M, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):260-6. doi: 10.1124/jpet.115.229278. Epub 2015 Dec 1. J Pharmacol Exp Ther. 2016. PMID: 26628406 Free PMC article.
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Rorick-Kehn LM, Witcher JW, Lowe SL, Gonzales CR, Weller MA, Bell RL, Hart JC, Need AB, McKinzie JH, Statnick MA, Suico JG, McKinzie DL, Tauscher-Wisniewski S, Mitch CH, Stoltz RR, Wong CJ. Rorick-Kehn LM, et al. Among authors: bell rl. Int J Neuropsychopharmacol. 2014 Oct 31;18(2):pyu036. doi: 10.1093/ijnp/pyu036. Int J Neuropsychopharmacol. 2014. PMID: 25637376 Free PMC article. Clinical Trial.
A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer.
Patnaik A, Haluska P, Tolcher AW, Erlichman C, Papadopoulos KP, Lensing JL, Beeram M, Molina JR, Rasco DW, Arcos RR, Kelly CS, Wijayawardana SR, Zhang X, Stancato LF, Bell R, Shi P, Kulanthaivel P, Pitou C, Mulle LB, Farrington DL, Chan EM, Goetz MP. Patnaik A, et al. Clin Cancer Res. 2016 Mar 1;22(5):1095-102. doi: 10.1158/1078-0432.CCR-15-1718. Epub 2015 Nov 18. Clin Cancer Res. 2016. PMID: 26581242 Clinical Trial.
A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer.
Vergote I, Heitz F, Buderath P, Powell M, Sehouli J, Lee CM, Hamilton A, Fiorica J, Moore KN, Teneriello M, Golden L, Zhang W, Pitou C, Bell R, Campbell R, Farrington DL, Bell-McGuinn K, Wenham RM. Vergote I, et al. Gynecol Oncol. 2020 Jan;156(1):23-31. doi: 10.1016/j.ygyno.2019.11.006. Epub 2019 Nov 29. Gynecol Oncol. 2020. PMID: 31791552 Clinical Trial.
Unveiling the genomic landscape of Salmonella enterica serotypes Typhimurium, Newport, and Infantis in Latin American surface waters: a comparative analysis.
Chen Z, Toro M, Moreno-Switt AI, Adell AD, Delgado-Suárez EJ, Bonelli RR, Oliveira CJB, Reyes-Jara A, Huang X, Albee B, Grim CJ, Allard M, Tallent SM, Brown EW, Bell RL, Meng J. Chen Z, et al. Among authors: bell rl. Microbiol Spectr. 2024 May 2;12(5):e0004724. doi: 10.1128/spectrum.00047-24. Epub 2024 Mar 28. Microbiol Spectr. 2024. PMID: 38546218 Free article.
Genomic characterisation of the population structure and antibiotic resistance of Salmonella enterica serovar Infantis in Chile, 2009-2022.
Piña-Iturbe A, Díaz-Gavidia C, Álvarez FP, Barron-Montenegro R, Álvarez-Espejo DM, García P, Solís D, Constenla-Albornoz R, Toro M, Olivares-Pacheco J, Reyes-Jara A, Meng J, Bell RL, Moreno-Switt AI. Piña-Iturbe A, et al. Among authors: bell rl. Lancet Reg Health Am. 2024 Mar 11;32:100711. doi: 10.1016/j.lana.2024.100711. eCollection 2024 Apr. Lancet Reg Health Am. 2024. PMID: 38495315 Free PMC article.
394 results