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Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin.
Grabarska A, Wróblewska-Łuczka P, Kukula-Koch W, Łuszczki JJ, Kalpoutzakis E, Adamczuk G, Skaltsounis AL, Stepulak A. Grabarska A, et al. Molecules. 2021 Oct 15;26(20):6253. doi: 10.3390/molecules26206253. Molecules. 2021. PMID: 34684834 Free PMC article.
Palmatine (PLT) is a natural isoquinoline alkaloid that belongs to the class of protoberberines and exhibits a wide spectrum of pharmacological and biological properties, including anti-cancer activity. The aim of our study was to isolate PLT from the roots of Berberis …
Palmatine (PLT) is a natural isoquinoline alkaloid that belongs to the class of protoberberines and exhibits a wide spectrum of pharmacologi …
Molecular Docking and In vitro Analysis of Fagonia Cretica and Berberis Lyceum Extracts Against Brucella Melitensis.
Muhammad I, Niaz S, Gul E Nayab, Hussain A, Ahmad S, Rahman N, Khan H, Ali A. Muhammad I, et al. Curr Comput Aided Drug Des. 2021;17(7):946-956. doi: 10.2174/1573409916666200612145712. Curr Comput Aided Drug Des. 2021. PMID: 32532195
METHODS: In the present study, crude ethanolic and methanolic extracts of local plants (Berberis lyceum and Fagonia cretica) were tested in vitro against Brucella melitensis via a well diffusion method for their antibacterial activity. ...RESULTS: Ethanolic crude ex …
METHODS: In the present study, crude ethanolic and methanolic extracts of local plants (Berberis lyceum and Fagonia cretica) w …
Magnoflorine-Isolation and the Anticancer Potential against NCI-H1299 Lung, MDA-MB-468 Breast, T98G Glioma, and TE671 Rhabdomyosarcoma Cancer Cells.
Okon E, Kukula-Koch W, Halasa M, Jarzab A, Baran M, Dmoszynska-Graniczka M, Angelis A, Kalpoutzakis E, Guz M, Stepulak A, Wawruszak A. Okon E, et al. Biomolecules. 2020 Nov 10;10(11):1532. doi: 10.3390/biom10111532. Biomolecules. 2020. PMID: 33182753 Free PMC article.
The aim of the present study was an investigation of the influence of MGN on viability, proliferation, induction of apoptosis, and cell cycle arrest in NCI-H1299 lung, MDA-MB-468 breast, T98G glioma, and TE671 rhabdomyosarcoma cancer cells. MGN was isolated from the roots of B …
The aim of the present study was an investigation of the influence of MGN on viability, proliferation, induction of apoptosis, and cell cycl …
Influence of extraction procedures on phenolic content and antioxidant activity of Cretan barberry herb.
Kukula-Koch W, Aligiannis N, Halabalaki M, Skaltsounis AL, Glowniak K, Kalpoutzakis E. Kukula-Koch W, et al. Food Chem. 2013 May 1;138(1):406-13. doi: 10.1016/j.foodchem.2012.10.045. Epub 2012 Nov 8. Food Chem. 2013. PMID: 23265505
The main goal of present study was the development, optimization and application of different extraction protocols, especially those employing green technologies, in order to obtain from Berberis cretica extracts with high antioxidant capacity. For this purpose, the …
The main goal of present study was the development, optimization and application of different extraction protocols, especially those employi …
The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling.
Kukula-Koch W, Kruk-Słomka M, Stępnik K, Szalak R, Biała G. Kukula-Koch W, et al. Int J Mol Sci. 2017 Nov 24;18(12):2511. doi: 10.3390/ijms18122511. Int J Mol Sci. 2017. PMID: 29186770 Free PMC article.
In the light of these findings, both compounds were purified from crude plant extracts of barberries: berberine-from Berberis siberica using a method published earlier, and magnoflorine-from Berberis cretica by centrifugal partition chromatography (solvent sy …
In the light of these findings, both compounds were purified from crude plant extracts of barberries: berberine-from Berberis siberic …
The effect of shrubland and grassland vegetation types on soil fauna and flora activities in a mountainous semi-arid landscape of Iran.
Kooch Y, Noghre N. Kooch Y, et al. Sci Total Environ. 2020 Feb 10;703:135497. doi: 10.1016/j.scitotenv.2019.135497. Epub 2019 Nov 14. Sci Total Environ. 2020. PMID: 31757532
Six vegetation types were selected with dominance in shrub and grassland coverage, i.e., (1) Crataegus microphylla CK. Koch., (2) Berberis integerrima Bunge, (3) Ribes uva-crispa L., (4) Prunus spinosa L., and with dominance in rangeland cover, i.e., (5) dominant Lecokia …
Six vegetation types were selected with dominance in shrub and grassland coverage, i.e., (1) Crataegus microphylla CK. Koch., (2) Berberi …