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Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles.
Migueles SA, Rood JE, Berkley AM, Guo T, Mendoza D, Patamawenu A, Hallahan CW, Cogliano NA, Frahm N, Duerr A, McElrath MJ, Connors M. Migueles SA, et al. Among authors: berkley am. PLoS Pathog. 2011 Feb;7(2):e1002002. doi: 10.1371/journal.ppat.1002002. Epub 2011 Feb 24. PLoS Pathog. 2011. PMID: 21383976 Free PMC article.
Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.
Migueles SA, Weeks KA, Nou E, Berkley AM, Rood JE, Osborne CM, Hallahan CW, Cogliano-Shutta NA, Metcalf JA, McLaughlin M, Kwan R, Mican JM, Davey RT Jr, Connors M. Migueles SA, et al. Among authors: berkley am. J Virol. 2009 Nov;83(22):11876-89. doi: 10.1128/JVI.01153-09. Epub 2009 Sep 2. J Virol. 2009. PMID: 19726501 Free PMC article. Clinical Trial.
Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells.
Patamawenu AA, Wright NE, Shofner T, Evans S, Manion MM, Doria-Rose N, Migueles SA, Mendoza D, Peterson B, Wilhelm C, Rood J, Berkley A, Cogliano NA, Liang CJ, Tesselaar K, Miedema F, Bess J Jr, Lifson J, Connors M. Patamawenu AA, et al. PLoS One. 2019 Dec 12;14(12):e0225806. doi: 10.1371/journal.pone.0225806. eCollection 2019. PLoS One. 2019. PMID: 31830058 Free PMC article.
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.
Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O'Shea MA, Mican J, Packard BZ, Komoriya A, Palmer S, Wiegand AP, Maldarelli F, Coffin JM, Mellors JW, Hallahan CW, Follman DA, Connors M. Migueles SA, et al. Among authors: berkley am. Immunity. 2008 Dec 19;29(6):1009-21. doi: 10.1016/j.immuni.2008.10.010. Epub 2008 Dec 8. Immunity. 2008. PMID: 19062316 Free PMC article.