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Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation.
Sáenz-de-Santa-María I, Bernardo-Castiñeira C, Secades P, Bernaldo-de-Quirós S, Rodrigo JP, Astudillo A, Chiara MD. Sáenz-de-Santa-María I, et al. Among authors: bernardo castineira c. Oncotarget. 2017 Feb 21;8(8):13730-13746. doi: 10.18632/oncotarget.14629. Oncotarget. 2017. PMID: 28099149 Free PMC article.
Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas.
Bernardo-Castiñeira C, Sáenz-de-Santa-María I, Valdés N, Astudillo A, Balbín M, Pitiot AS, Jiménez-Fonseca P, Scola B, Tena I, Molina-Garrido MJ, Sevilla MA, Beristein E, Forga L, Villabona C, Oriola J, Halperin I, Suarez C, Chiara MD. Bernardo-Castiñeira C, et al. Head Neck. 2019 Jan;41(1):79-91. doi: 10.1002/hed.25386. Epub 2018 Dec 14. Head Neck. 2019. PMID: 30549360
SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas.
Bernardo-Castiñeira C, Valdés N, Sierra MI, Sáenz-de-Santa-María I, Bayón GF, Perez RF, Fernández AF, Fraga MF, Astudillo A, Menéndez R, Fernández B, Del Olmo M, Suarez C, Chiara MD. Bernardo-Castiñeira C, et al. J Clin Endocrinol Metab. 2018 Jan 1;103(1):295-305. doi: 10.1210/jc.2017-01702. J Clin Endocrinol Metab. 2018. PMID: 29126304
Epigenetic Deregulation of Protocadherin PCDHGC3 in Pheochromocytomas/Paragangliomas Associated With SDHB Mutations.
Bernardo-Castiñeira C, Valdés N, Celada L, Martinez ASJ, Sáenz-de-Santa-María I, Bayón GF, Fernández AF, Sierra MI, Fraga MF, Astudillo A, Jiménez-Fonseca P, Rial JC, Hevia MÁ, Turienzo E, Bernardo C, Forga L, Tena I, Molina-Garrido MJ, Cacho L, Villabona C, Serrano T, Scola B, Chirivella I, Del Olmo M, Menéndez CL, Navarro E, Tous M, Vallejo A, Athimulam S, Bancos I, Suarez C, Chiara MD. Bernardo-Castiñeira C, et al. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5673-5692. doi: 10.1210/jc.2018-01471. J Clin Endocrinol Metab. 2019. PMID: 31216007 Free article.