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A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells.
Cubitt CC, McClain E, Becker-Hapak M, Foltz JA, Wong P, Wagner JA, Neal CC, Marin ND, Marsala L, Foster M, Schappe T, Soon-Shiong P, Lee J, Berrien-Elliott MM, Fehniger TA. Cubitt CC, et al. Among authors: berrien elliott mm. Mol Ther Oncolytics. 2022 Feb 15;24:585-596. doi: 10.1016/j.omto.2022.02.009. eCollection 2022 Mar 17. Mol Ther Oncolytics. 2022. PMID: 35284622 Free PMC article.
Human Cytokine-Induced Memory-Like Natural Killer Cells.
Berrien-Elliott MM, Wagner JA, Fehniger TA. Berrien-Elliott MM, et al. J Innate Immun. 2015;7(6):563-71. doi: 10.1159/000382019. Epub 2015 Apr 30. J Innate Immun. 2015. PMID: 25924651 Free PMC article. Review.
MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation.
Sullivan RP, Leong JW, Schneider SE, Ireland AR, Berrien-Elliott MM, Singh A, Schappe T, Jewell BA, Sexl V, Fehniger TA. Sullivan RP, et al. J Immunol. 2015 Sep 15;195(6):2806-17. doi: 10.4049/jimmunol.1500949. Epub 2015 Aug 12. J Immunol. 2015. PMID: 26268657 Free PMC article.
Improving natural killer cell cancer immunotherapy.
Berrien-Elliott MM, Romee R, Fehniger TA. Berrien-Elliott MM, et al. Curr Opin Organ Transplant. 2015 Dec;20(6):671-80. doi: 10.1097/MOT.0000000000000243. Curr Opin Organ Transplant. 2015. PMID: 26414502 Free PMC article. Review.
Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia.
Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S, Neal CC, Yu L, Oh ST, Lee YS, Mulder A, Claas F, Cooper MA, Fehniger TA. Romee R, et al. Sci Transl Med. 2016 Sep 21;8(357):357ra123. doi: 10.1126/scitranslmed.aaf2341. Sci Transl Med. 2016. PMID: 27655849 Free PMC article. Clinical Trial.
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming.
Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell BA, Becker-Hapak M, Schappe T, Abdel-Latif S, Ireland AR, Jaishankar D, King JA, Vij R, Clement D, Goodridge J, Malmberg KJ, Wong HC, Fehniger TA. Wagner JA, et al. J Clin Invest. 2017 Nov 1;127(11):4042-4058. doi: 10.1172/JCI90387. Epub 2017 Oct 3. J Clin Invest. 2017. PMID: 28972539 Free PMC article.
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation.
Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, Weisdorf DJ, Blazar BR, Ustun C, DeFor TE, Vivek S, Peck L, DiPersio JF, Cashen AF, Kyllo R, Musiek A, Schaffer A, Anadkat MJ, Rosman I, Miller D, Egan JO, Jeng EK, Rock A, Wong HC, Fehniger TA, Miller JS. Romee R, et al. Blood. 2018 Jun 7;131(23):2515-2527. doi: 10.1182/blood-2017-12-823757. Epub 2018 Feb 20. Blood. 2018. PMID: 29463563 Free PMC article. Clinical Trial.
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