Beurskens FJ - Search Results

1

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

de Haij S, Jansen JH, Boross P, Beurskens FJ, Bakema JE, Bos DL, Martens A, Verbeek JS, Parren PW, van de Winkel JG, Leusen JH. de Haij S, et al. Among authors: beurskens fj. Cancer Res. 2010 Apr 15;70(8):3209-17. doi: 10.1158/0008-5472.CAN-09-4109. Epub 2010 Mar 30. Cancer Res. 2010. PMID: 20354182

2

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.

Villadsen LS, Schuurman J, Beurskens F, Dam TN, Dagnaes-Hansen F, Skov L, Rygaard J, Voorhorst-Ogink MM, Gerritsen AF, van Dijk MA, Parren PW, Baadsgaard O, van de Winkel JG. Villadsen LS, et al. J Clin Invest. 2003 Nov;112(10):1571-80. doi: 10.1172/JCI18986. J Clin Invest. 2003. PMID: 14617758 Free PMC article.

3

Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study.

Baslund B, Tvede N, Danneskiold-Samsoe B, Larsson P, Panayi G, Petersen J, Petersen LJ, Beurskens FJ, Schuurman J, van de Winkel JG, Parren PW, Gracie JA, Jongbloed S, Liew FY, McInnes IB. Baslund B, et al. Among authors: beurskens fj. Arthritis Rheum. 2005 Sep;52(9):2686-92. doi: 10.1002/art.21249. Arthritis Rheum. 2005. PMID: 16142748 Free article. Clinical Trial.

4

Fc receptor but not complement binding is important in antibody protection against HIV.

Hessell AJ, Hangartner L, Hunter M, Havenith CE, Beurskens FJ, Bakker JM, Lanigan CM, Landucci G, Forthal DN, Parren PW, Marx PA, Burton DR. Hessell AJ, et al. Among authors: beurskens fj. Nature. 2007 Sep 6;449(7158):101-4. doi: 10.1038/nature06106. Nature. 2007. PMID: 17805298

5

IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis.

Skov L, Beurskens FJ, Zachariae CO, Reitamo S, Teeling J, Satijn D, Knudsen KM, Boot EP, Hudson D, Baadsgaard O, Parren PW, van de Winkel JG. Skov L, et al. Among authors: beurskens fj. J Immunol. 2008 Jul 1;181(1):669-79. doi: 10.4049/jimmunol.181.1.669. J Immunol. 2008. PMID: 18566434

6

Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis.

Beum PV, Lindorfer MA, Beurskens F, Stukenberg PT, Lokhorst HM, Pawluczkowycz AW, Parren PW, van de Winkel JG, Taylor RP. Beum PV, et al. J Immunol. 2008 Jul 1;181(1):822-32. doi: 10.4049/jimmunol.181.1.822. J Immunol. 2008. PMID: 18566448

7

Complement activation impacts B-cell depletion by both type I and type II CD20 monoclonal antibodies.

Beurskens FJ, Ruuls SR, Engelberts PJ, Vink T, Mackus WJ, van de Winkel JG, Parren PW. Beurskens FJ, et al. Blood. 2008 Nov 15;112(10):4354-5; author reply 4355-6. doi: 10.1182/blood-2008-07-171082. Blood. 2008. PMID: 18988880 Free article. No abstract available.

8

Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX.

Pawluczkowycz AW, Beurskens FJ, Beum PV, Lindorfer MA, van de Winkel JG, Parren PW, Taylor RP. Pawluczkowycz AW, et al. Among authors: beurskens fj. J Immunol. 2009 Jul 1;183(1):749-58. doi: 10.4049/jimmunol.0900632. Epub 2009 Jun 17. J Immunol. 2009. PMID: 19535640

9

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca(2+) influx and induces streamers.

Beum PV, Lindorfer MA, Peek EM, Stukenberg PT, de Weers M, Beurskens FJ, Parren PW, van de Winkel JG, Taylor RP. Beum PV, et al. Among authors: beurskens fj. Eur J Immunol. 2011 Aug;41(8):2436-46. doi: 10.1002/eji.201041204. Epub 2011 Jul 4. Eur J Immunol. 2011. PMID: 21674476 Free article.

10

Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells.

Beum PV, Peek EM, Lindorfer MA, Beurskens FJ, Engelberts PJ, Parren PW, van de Winkel JG, Taylor RP. Beum PV, et al. Among authors: beurskens fj. J Immunol. 2011 Sep 15;187(6):3438-47. doi: 10.4049/jimmunol.1101189. Epub 2011 Aug 12. J Immunol. 2011. PMID: 21841127

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