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Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
Madar DJ, Kopecka H, Pireh D, Yong H, Pei Z, Li X, Wiedeman PE, Djuric SW, Von Geldern TW, Fickes MG, Bhagavatula L, McDermott T, Wittenberger S, Richards SJ, Longenecker KL, Stewart KD, Lubben TH, Ballaron SJ, Stashko MA, Long MA, Wells H, Zinker BA, Mika AK, Beno DW, Kempf-Grote AJ, Polakowski J, Segreti J, Reinhart GA, Fryer RM, Sham HL, Trevillyan JM. Madar DJ, et al. Among authors: bhagavatula l. J Med Chem. 2006 Oct 19;49(21):6416-20. doi: 10.1021/jm060777o. J Med Chem. 2006. PMID: 17034148
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
Pei Z, Li X, Longenecker K, von Geldern TW, Wiedeman PE, Lubben TH, Zinker BA, Stewart K, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Long M, Wells H, Kempf-Grote AJ, Madar DJ, McDermott TS, Bhagavatula L, Fickes MG, Pireh D, Solomon LR, Lake MR, Edalji R, Fry EH, Sham HL, Trevillyan JM. Pei Z, et al. Among authors: bhagavatula l. J Med Chem. 2006 Jun 15;49(12):3520-35. doi: 10.1021/jm051283e. J Med Chem. 2006. PMID: 16759095
Interplay of Light and ABA signaling to modulate plant development.
Mahapatra K, Dwivedi S, Mukherjee A, Pradhan AA, Rao KV, Singh D, Bhagavatula L, Datta S. Mahapatra K, et al. Among authors: bhagavatula l. J Exp Bot. 2024 Apr 25:erae192. doi: 10.1093/jxb/erae192. Online ahead of print. J Exp Bot. 2024. PMID: 38660968
Plant microProteins: Small but powerful modulators of plant development.
Kushwaha AK, Dwivedi S, Mukherjee A, Lingwan M, Dar MA, Bhagavatula L, Datta S. Kushwaha AK, et al. Among authors: bhagavatula l. iScience. 2022 Oct 21;25(11):105400. doi: 10.1016/j.isci.2022.105400. eCollection 2022 Nov 18. iScience. 2022. PMID: 36353725 Free PMC article. Review.
The multitasking abilities of MATE transporters in plants.
Upadhyay N, Kar D, Deepak Mahajan B, Nanda S, Rahiman R, Panchakshari N, Bhagavatula L, Datta S. Upadhyay N, et al. Among authors: bhagavatula l. J Exp Bot. 2019 Sep 24;70(18):4643-4656. doi: 10.1093/jxb/erz246. J Exp Bot. 2019. PMID: 31106838 Review.
Quantal release of transmitter at a central synapse.
Sastry BR, Bhagavatula LS. Sastry BR, et al. Among authors: bhagavatula ls. Neuroscience. 1996 Dec;75(4):987-92. doi: 10.1016/0306-4522(96)00348-x. Neuroscience. 1996. PMID: 8938734