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The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability.
Predmore BL, Kondo K, Bhushan S, Zlatopolsky MA, King AL, Aragon JP, Grinsfelder DB, Condit ME, Lefer DJ. Predmore BL, et al. Among authors: bhushan s. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2410-8. doi: 10.1152/ajpheart.00044.2012. Epub 2012 Mar 30. Am J Physiol Heart Circ Physiol. 2012. PMID: 22467307 Free PMC article.
H₂S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase.
Kondo K, Bhushan S, King AL, Prabhu SD, Hamid T, Koenig S, Murohara T, Predmore BL, Gojon G Sr, Gojon G Jr, Wang R, Karusula N, Nicholson CK, Calvert JW, Lefer DJ. Kondo K, et al. Among authors: bhushan s. Circulation. 2013 Mar 12;127(10):1116-27. doi: 10.1161/CIRCULATIONAHA.112.000855. Epub 2013 Feb 7. Circulation. 2013. PMID: 23393010 Free PMC article.
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.
King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ. King AL, et al. Among authors: bhushan s. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3182-7. doi: 10.1073/pnas.1321871111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516168 Free PMC article.
Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation.
Aragón JP, Condit ME, Bhushan S, Predmore BL, Patel SS, Grinsfelder DB, Gundewar S, Jha S, Calvert JW, Barouch LA, Lavu M, Wright HM, Lefer DJ. Aragón JP, et al. Among authors: bhushan s. J Am Coll Cardiol. 2011 Dec 13;58(25):2683-91. doi: 10.1016/j.jacc.2011.09.033. J Am Coll Cardiol. 2011. PMID: 22152956 Free PMC article.
392 results