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657 results

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Page 1
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Sudwarts A, Ramesha S, Gao T, Ponnusamy M, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, Rangaraju S. Sudwarts A, et al. Mol Neurodegener. 2022 May 7;17(1):33. doi: 10.1186/s13024-022-00535-x. Mol Neurodegener. 2022. PMID: 35526014 Free PMC article.
BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dynamics in a range of crucial cellular processes. Whilst the expression of BIN1 in the brain has been characterized in neurons and oligodendro …
BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dynamics i …
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Perdreau-Dahl H, Lipsett DB, Frisk M, Kermani F, Carlson CR, Brech A, Shen X, Bergan-Dahl A, Hou Y, Tuomainen T, Tavi P, Jones PP, Lunde M, Wasserstrom JA, Laporte J, Ullrich ND, Christensen G, Morth JP, Louch WE. Perdreau-Dahl H, et al. Circ Res. 2023 May 26;132(11):e188-e205. doi: 10.1161/CIRCRESAHA.122.321732. Epub 2023 May 4. Circ Res. 2023. PMID: 37139790 Free article.
BIN1 upregulation during development was paralleled by increasing expression of MTM1. Despite no direct binding between MTM1 and murine cardiac BIN1 isoforms, which lack exon 11, high MTM1 levels were necessary for BIN1-induced tubulation, indicating a centra …
BIN1 upregulation during development was paralleled by increasing expression of MTM1. Despite no direct binding between MTM1 and muri …
BIN1 in cancer: biomarker and therapeutic target.
Chen SY, Cao JL, Li KP, Wan S, Yang L. Chen SY, et al. J Cancer Res Clin Oncol. 2023 Aug;149(10):7933-7944. doi: 10.1007/s00432-023-04673-7. Epub 2023 Mar 9. J Cancer Res Clin Oncol. 2023. PMID: 36890396 Review.
PURPOSE: Because BIN1 is commonly expressed in terminally differentiated normal tissues and is usually undetectable in refractory or metastatic cancer tissues, this differential expression has led us to focus on human cancers associated with BIN1. ...It also makes …
PURPOSE: Because BIN1 is commonly expressed in terminally differentiated normal tissues and is usually undetectable in refractory or …
Effect of BIN1 on cardiac dysfunction and malignant arrhythmias.
Jiang XX, Zhu YR, Liu HM, Chen SL, Zhang DM. Jiang XX, et al. Acta Physiol (Oxf). 2020 Mar;228(3):e13429. doi: 10.1111/apha.13429. Epub 2019 Dec 26. Acta Physiol (Oxf). 2020. PMID: 31837094 Review.
Because of the detectability of cardiac BIN1 in peripheral blood, BIN1 may serve as a predictor of HF and may be useful in therapy development. However, the mechanism of BIN1 downregulation in HF and how BIN1 regulates normal cardiac function under phy …
Because of the detectability of cardiac BIN1 in peripheral blood, BIN1 may serve as a predictor of HF and may be useful in the …
BIN1 in the Pursuit of Ousting the Alzheimer's Reign: Impact on Amyloid and Tau Neuropathology.
Kaur I, Behl T, Sundararajan G, Panneerselvam P, Vijayakumar AR, Senthilkumar GP, Venkatachalam T, Jaglan D, Yadav S, Anwer K, Fuloria NK, Sehgal A, Gulati M, Chigurupati S. Kaur I, et al. Neurotox Res. 2023 Dec;41(6):698-707. doi: 10.1007/s12640-023-00670-3. Epub 2023 Oct 17. Neurotox Res. 2023. PMID: 37847429 Review.
Two BIN1 mutants, KR and PL, were identified to exhibit Abeta accumulation. Furthermore, BIN1 deficiency by BIN1-related polymorphisms impairs the interaction with tau, thus elevating tau phosphorylation, altering synapse structure and tau function. ...
Two BIN1 mutants, KR and PL, were identified to exhibit Abeta accumulation. Furthermore, BIN1 deficiency by BIN1-relate …
Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1.
Lin J, Wang X, Zhai S, Shi M, Peng C, Deng X, Fu D, Wang J, Shen B. Lin J, et al. J Hematol Oncol. 2022 Sep 6;15(1):128. doi: 10.1186/s13045-022-01348-7. J Hematol Oncol. 2022. PMID: 36068586 Free PMC article.
In addition, circPDK1 serves as a scaffold that enhances the interaction between UBE2O and BIN1, inducing the UBE2O-mediated degradation of BIN1. CONCLUSIONS: We found that circPDK1 was activated by HIF1A at the transcriptional level by modulating the miR-628-3p/BPT …
In addition, circPDK1 serves as a scaffold that enhances the interaction between UBE2O and BIN1, inducing the UBE2O-mediated degradat …
BIN1 regulates dynamic t-tubule membrane.
Fu Y, Hong T. Fu Y, et al. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1839-47. doi: 10.1016/j.bbamcr.2015.11.004. Epub 2015 Nov 11. Biochim Biophys Acta. 2016. PMID: 26578114 Free PMC article. Review.
Secondly, we highlight multiple aspects of BIN1-dependent t-tubule function, which includes forward trafficking of LTCCs to t-tubules, LTCC clustering at t-tubule surface, microdomain organization and regulation at t-tubule membrane, and the formation of a slow diffusion b …
Secondly, we highlight multiple aspects of BIN1-dependent t-tubule function, which includes forward trafficking of LTCCs to t-tubules …
Amphiphysin-2 (BIN1) functions and defects in cardiac and skeletal muscle.
Giraud Q, Laporte J. Giraud Q, et al. Trends Mol Med. 2024 Mar 20:S1471-4914(24)00030-3. doi: 10.1016/j.molmed.2024.02.005. Online ahead of print. Trends Mol Med. 2024. PMID: 38514365 Review.
Mutations in the gene encoding BIN1 cause centronuclear myopathies (CNM), and recent evidence has implicated BIN1 in heart failure, underlining its crucial role in both skeletal and cardiac muscle. ...Recently, the first proof-of-concept for potential therapeutic st …
Mutations in the gene encoding BIN1 cause centronuclear myopathies (CNM), and recent evidence has implicated BIN1 in heart fai …
Amphiphysin 2 (BIN1) in physiology and diseases.
Prokic I, Cowling BS, Laporte J. Prokic I, et al. J Mol Med (Berl). 2014 May;92(5):453-63. doi: 10.1007/s00109-014-1138-1. Epub 2014 Mar 5. J Mol Med (Berl). 2014. PMID: 24590001 Review.
Increased BIN1 expression is linked to increased susceptibility for late-onset Alzheimer's disease. ...Next challenges will be to validate BIN1 both as a prognostic marker for the related diseases and as a potential therapeutic target....
Increased BIN1 expression is linked to increased susceptibility for late-onset Alzheimer's disease. ...Next challenges will be to val …
BIN1 rs744373 SNP and COVID-19 mortality.
Lehrer S, Rheinstein PH. Lehrer S, et al. World Acad Sci J. 2021 Mar-Apr;3(2):13. doi: 10.3892/wasj.2021.84. Epub 2021 Jan 14. World Acad Sci J. 2021. PMID: 33521641 Free PMC article.
The objective of the present study was to evaluate the effects of BIN1 and the SNP rs744373 on COVID-19-relaetd survival using UKB-derived data. In addition, the interaction and alignment of BIN1 and SARS-Cov-2 were evaluated. For this purpose, the major (non-Alzhei …
The objective of the present study was to evaluate the effects of BIN1 and the SNP rs744373 on COVID-19-relaetd survival using UKB-de …
657 results