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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1970 1
1971 1
1973 1
1975 2
1976 4
1977 2
1979 1
1981 3
1982 1
1983 2
1984 2
1985 10
1986 7
1987 11
1988 17
1989 22
1990 26
1991 32
1992 37
1993 36
1994 38
1995 47
1996 34
1997 67
1998 68
1999 80
2000 96
2001 117
2002 155
2003 235
2004 282
2005 271
2006 282
2007 297
2008 296
2009 323
2010 283
2011 331
2012 290
2013 363
2014 415
2015 389
2016 423
2017 387
2018 450
2019 503
2020 483
2021 532
2022 569
2023 588
2024 298

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8,626 results

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Page 1
Showing results for binding yi
Search for Binbin Yi instead (1 results)
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Li X, et al. Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019. Immunity. 2013. PMID: 24332030 Free PMC article.
The structure of mouse cGAS bound to an 18 bp dsDNA revealed that cGAS interacts with dsDNA through two binding sites, forming a 2:2 complex. Enzyme assays and IFN-beta reporter assays of cGAS mutants demonstrated that interactions at both DNA binding sites are esse …
The structure of mouse cGAS bound to an 18 bp dsDNA revealed that cGAS interacts with dsDNA through two binding sites, forming a 2:2 …
Tail engagement of arrestin at the glucagon receptor.
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B. Chen K, et al. Nature. 2023 Aug;620(7975):904-910. doi: 10.1038/s41586-023-06420-x. Epub 2023 Aug 9. Nature. 2023. PMID: 37558880 Free PMC article.
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating receptor internalization(1,2). It has been proposed that the arrestin binds to the receptor in two different conformations, 'tail' an …
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating …
Doublecortin-like kinase 1 activates NF-kappaB to induce inflammatory responses by binding directly to IKKbeta.
Luo W, Jin Y, Jiang Y, Yang L, Xu H, Wu D, Zhang Y, Yin L, Khan ZA, Liang G, Wang Y. Luo W, et al. Cell Death Differ. 2023 May;30(5):1184-1197. doi: 10.1038/s41418-023-01147-8. Epub 2023 Mar 13. Cell Death Differ. 2023. PMID: 36914767 Free PMC article.
Through a range of macrophage-based and cell-free platforms, we discovered that DCLK1 binds directly with the inhibitor of kappaB kinase beta (IKKbeta) and induces IKKbeta phosphorylation on Ser177/181 to initiate nuclear factor-kappaB (NF-kappaB) pathway. ...
Through a range of macrophage-based and cell-free platforms, we discovered that DCLK1 binds directly with the inhibitor of kappaB kin …
The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.
Wang Y, Zhu W, Jang Y, Sommers JA, Yi G, Puligilla C, Croteau DL, Yang Y, Kai M, Liu Y. Wang Y, et al. Nucleic Acids Res. 2023 Dec 11;51(22):12242-12260. doi: 10.1093/nar/gkad967. Nucleic Acids Res. 2023. PMID: 37930826 Free PMC article.
Telomeric repeat-containing RNA (TERRA) and its formation of RNA:DNA hybrids (or TERRA R-loops), influence telomere maintenance, particularly in human cancer cells that use homologous recombination-mediated alternative lengthening of telomeres. Here, we report that the RNA-bin …
Telomeric repeat-containing RNA (TERRA) and its formation of RNA:DNA hybrids (or TERRA R-loops), influence telomere maintenance, particularl …
MLL4 binds TET3.
Becht DC, Mohid SA, Lee JE, Zandian M, Benz C, Biswas S, Sinha VK, Ivarsson Y, Ge K, Zhang Y, Kutateladze TG. Becht DC, et al. Structure. 2024 Jun 6;32(6):706-714.e3. doi: 10.1016/j.str.2024.03.005. Epub 2024 Apr 4. Structure. 2024. PMID: 38579707
Here, we report that the sixth PHD finger of MLL4 (MLL4(PHD6)) binds to the hydrophobic motif of ten-eleven translocation 3 (TET3), a dioxygenase that converts methylated cytosine into oxidized derivatives. The solution NMR structure of the TET3-MLL4(PHD6) complex and b …
Here, we report that the sixth PHD finger of MLL4 (MLL4(PHD6)) binds to the hydrophobic motif of ten-eleven translocation 3 (TET3), a …
Epitranscriptomic technologies and analyses.
Li X, Liang QX, Lin JR, Peng J, Yang JH, Yi C, Yu Y, Zhang QC, Zhou KR. Li X, et al. Sci China Life Sci. 2020 Apr;63(4):501-515. doi: 10.1007/s11427-019-1658-x. Epub 2020 Mar 11. Sci China Life Sci. 2020. PMID: 32170629 Review.
RNA can interact with RNA-binding proteins (RBPs), mRNA, or other non-coding RNAs (ncRNAs) to form complex regulatory networks. ...However, assigning ncRNAs to their regulatory target genes or interacting RNA-binding proteins (RBPs) remains technically challenging. …
RNA can interact with RNA-binding proteins (RBPs), mRNA, or other non-coding RNAs (ncRNAs) to form complex regulatory networks. ...Ho …
TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer.
Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O'Malley BW, Yi P. Singh R, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2218229120. doi: 10.1073/pnas.2218229120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155905 Free PMC article.
Several lines of evidence indicate that AR induces a distinct transcriptional program after androgen deprivation in CRPCs. However, the mechanism triggering AR binding to a distinct set of genomic loci in CRPC and how it promotes CRPC development remain unclear. ...It medi …
Several lines of evidence indicate that AR induces a distinct transcriptional program after androgen deprivation in CRPCs. However, the mech …
The Binding Receptors of Abeta: an Alternative Therapeutic Target for Alzheimer's Disease.
Xia M, Cheng X, Yi R, Gao D, Xiong J. Xia M, et al. Mol Neurobiol. 2016 Jan;53(1):455-471. doi: 10.1007/s12035-014-8994-0. Epub 2014 Dec 4. Mol Neurobiol. 2016. PMID: 25465238 Review.
This review summarizes the characters of these prominent receptors and how the bindings of them with Abeta inhibit the LTP, decrease the number of dendritic spine, damage the neurons, and so on in AD pathogenesis. ...
This review summarizes the characters of these prominent receptors and how the bindings of them with Abeta inhibit the LTP, decrease …
RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review).
Sun W, Cui H, Xu T, Yue J, Liang J, You W, Sun W, Yi Q. Sun W, et al. Int J Oncol. 2023 Oct;63(4):114. doi: 10.3892/ijo.2023.5562. Epub 2023 Aug 18. Int J Oncol. 2023. PMID: 37594130 Review.
Of note, cells can selectively sort these bioactive molecules (particularly RNAs) into EVs for secretion, as well as regulate cell-cell communications. RNA-binding proteins (RBPs) are a large class of proteins capable of binding to RNA molecules and function in regu …
Of note, cells can selectively sort these bioactive molecules (particularly RNAs) into EVs for secretion, as well as regulate cell-cell comm …
Smad3-mediated lncRNA HSALR1 enhances the non-classic signalling pathway of TGF-beta1 in human bronchial fibroblasts by binding to HSP90AB1.
Yi E, Lin B, Zhang Y, Wang X, Zhang J, Liu Y, Jin J, Hong W, Lin Z, Cao W, Mei X, Bai G, Li B, Zhou Y, Ran P. Yi E, et al. Clin Transl Med. 2023 Jun;13(6):e1292. doi: 10.1002/ctm2.1292. Clin Transl Med. 2023. PMID: 37317677 Free PMC article.
Mechanistically, it could directly bind to HSP90AB1 protein, and acted as a scaffold to stabilize the binding between Akt and HSP90AB1 to promote Akt phosphorylation. In vivo, mice expressed HSALR1 by AAV was exposure to cigarette smoke (CS) for COPD modeling. We found tha …
Mechanistically, it could directly bind to HSP90AB1 protein, and acted as a scaffold to stabilize the binding between Akt and HSP90AB …
8,626 results