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Ofatumumab and Complement Replacement in Relapsed/Refractory Chronic Lymphocytic Leukemia.
Tuscano J, Poh C, Rosenberg A, Jonas B, Abedi M, Barisone G, Schwab E, Lundeberg K, Kaesberg P. Tuscano J, et al. J Hematol. 2020 Sep;9(3):79-83. doi: 10.14740/jh721. Epub 2020 Aug 14. J Hematol. 2020. PMID: 32855756 Free PMC article.
The primary endpoint was objective response rate. Correlative endpoints included complement levels (C3 and C4) and complement activity (CH50) which was drawn at baseline and after ofatumumab with FFP administration. ...
The primary endpoint was objective response rate. Correlative endpoints included complement levels (C3 and C4) and complement activit …
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J. Schubart A, et al. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926668 Free PMC article.
Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and C3 glomerulopathy. Moreover, glomerular Ig deposits can lead to complement-driven …
Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemo …
[The clinical significance of CD(4)(+)CD(69)(+) T lymphocytes in patients with autoimmune hemolytic anemia/Evans syndrome].
Xing LM, Xu WY, Duan NN, Qu YY, Liu ZY, Shao ZH. Xing LM, et al. Zhonghua Nei Ke Za Zhi. 2018 Sep 1;57(9):656-660. doi: 10.3760/cma.j.issn.0578-1426.2018.09.007. Zhonghua Nei Ke Za Zhi. 2018. PMID: 30180450 Chinese.
Objective: To investigate the significant of peripheral CD(4)(+) CD(69)(+) T lymphocytes in patients with autoimmune hemolytic anemia (AIHA)/Evans syndrome (ES). Methods: In this study peripheral blood samples from 32 patients with AIHA/ES (15 hemolytic episode pati …
Objective: To investigate the significant of peripheral CD(4)(+) CD(69)(+) T lymphocytes in patients with autoimmune hemolytic anemia (AIHA) …
Body plethysmography in chronic obstructive pulmonary disease patients: A cross-sectional study.
Gupta YS, Shah SS, Ahire CK, Kamble P, Khare AS, More SS. Gupta YS, et al. Lung India. 2018 Mar-Apr;35(2):127-131. doi: 10.4103/lungindia.lungindia_238_17. Lung India. 2018. PMID: 29487247 Free PMC article.
Hence, we conducted this study to assess parameters of body plethysmography in Indian population where the data are lacking and to assess whether the use of body plethysmography can detect COPD earlier. SUBJECTS AND METHODS: The study was approved by the Ethics Committee a …
Hence, we conducted this study to assess parameters of body plethysmography in Indian population where the data are lacking and to assess wh …
Metabolism of γ-hydroxybutyrate in perfused rat livers.
Zhang GF, Sadhukhan S, Ibarra RA, Lauden SM, Chuang CY, Sushailo S, Chatterjee P, Anderson VE, Tochtrop GP, Brunengraber H. Zhang GF, et al. Biochem J. 2012 Jun 1;444(2):333-41. doi: 10.1042/BJ20112046. Biochem J. 2012. PMID: 22428548
Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids.
Ciccoli R, Sahi S, Singh S, Prakash H, Zafiriou MP, Ishdorj G, Kock JL, Nigam S. Ciccoli R, et al. Biochem J. 2005 Sep 15;390(Pt 3):737-47. doi: 10.1042/BJ20041995. Biochem J. 2005. PMID: 15869467 Free PMC article.
Oxygenation of 3-HETE by COX-2 produced a novel cascade of 3-hydroxyeicosanoids, as identified with EI (electron impact)-GC-MS, LC-MS-ES (electrospray) and LC-MS-API (atmospheric pressure ionization) methods. ...
Oxygenation of 3-HETE by COX-2 produced a novel cascade of 3-hydroxyeicosanoids, as identified with EI (electron impact)-GC-MS, LC-MS-ES …
Purification and properties of the membrane-bound by hydrogenase from Desulfovibrio desulfuricans.
Lalla-Maharajh WV, Hall DO, Cammack R, Rao KK, Le Gall J. Lalla-Maharajh WV, et al. Biochem J. 1983 Feb 1;209(2):445-54. doi: 10.1042/bj2090445. Biochem J. 1983. PMID: 6303306 Free PMC article.
It catalyses both H2-evolution and H2-uptake with a variety of artificial electron carriers. D. desulfuricans cytochrome C3, its natural electron carrier, had a high affinity for the enzyme (Km = 2 microns). Rate enhancement was observed when cytochrome C3 was added …
It catalyses both H2-evolution and H2-uptake with a variety of artificial electron carriers. D. desulfuricans cytochrome C3, its natu …