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Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier.
Bioorg Med Chem Lett. 2010 Jan 15;20(2):453-7. doi: 10.1016/j.bmcl.2009.12.003. Epub 2009 Dec 4.
Bioorg Med Chem Lett. 2010.
PMID: 20015647
4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists.
Receveur JM, Bjurling E, Ulven T, Little PB, Nørregaard PK, Högberg T.
Receveur JM, et al. Among authors: bjurling e.
Bioorg Med Chem Lett. 2004 Oct 18;14(20):5075-80. doi: 10.1016/j.bmcl.2004.07.077.
Bioorg Med Chem Lett. 2004.
PMID: 15380202
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Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists.
Cooper M, Receveur JM, Bjurling E, Nørregaard PK, Nielsen PA, Sköld N, Högberg T.
Cooper M, et al. Among authors: bjurling e.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):26-30. doi: 10.1016/j.bmcl.2009.11.047. Epub 2009 Nov 15.
Bioorg Med Chem Lett. 2010.
PMID: 19954978
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Vorapaxar in the secondary prevention of atherothrombotic events.
Morrow DA, Braunwald E, Bonaca MP, Ameriso SF, Dalby AJ, Fish MP, Fox KA, Lipka LJ, Liu X, Nicolau JC, Ophuis AJ, Paolasso E, Scirica BM, Spinar J, Theroux P, Wiviott SD, Strony J, Murphy SA; TRA 2P–TIMI 50 Steering Committee and Investigators.
Morrow DA, et al.
N Engl J Med. 2012 Apr 12;366(15):1404-13. doi: 10.1056/NEJMoa1200933. Epub 2012 Mar 24.
N Engl J Med. 2012.
PMID: 22443427
Free article.
Clinical Trial.
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