Blake A - Search Results

1

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP. Ye Z, et al. Among authors: blake a. Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8. doi: 10.1016/s0960-894x(99)00584-3. Bioorg Med Chem Lett. 2000. PMID: 10636230

2

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. Rohrer SP, et al. Among authors: blake a. Science. 1998 Oct 23;282(5389):737-40. doi: 10.1126/science.282.5389.737. Science. 1998. PMID: 9784130

3

Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites.

Blake AD, Smith RG. Blake AD, et al. J Endocrinol. 1991 Apr;129(1):11-9. doi: 10.1677/joe.0.1290011. J Endocrinol. 1991. PMID: 1674284

4

Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells.

Parmar RM, Chan WW, Dashkevicz M, Hayes EC, Rohrer SP, Smith RG, Schaeffer JM, Blake AD. Parmar RM, et al. Among authors: blake ad. Biochem Biophys Res Commun. 1999 Sep 24;263(2):276-80. doi: 10.1006/bbrc.1999.1376. Biochem Biophys Res Commun. 1999. PMID: 10491284

5

Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.

Strowski MZ, Parmar RM, Blake AD, Schaeffer JM. Strowski MZ, et al. Among authors: blake ad. Endocrinology. 2000 Jan;141(1):111-7. doi: 10.1210/endo.141.1.7263. Endocrinology. 2000. PMID: 10614629

6

Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells.

Strowski MZ, Dashkevicz MP, Parmar RM, Wilkinson H, Kohler M, Schaeffer JM, Blake AD. Strowski MZ, et al. Neuroendocrinology. 2002 Jun;75(6):339-46. doi: 10.1159/000059430. Neuroendocrinology. 2002. PMID: 12065886

7

Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.

Strowski MZ, Kohler M, Chen HY, Trumbauer ME, Li Z, Szalkowski D, Gopal-Truter S, Fisher JK, Schaeffer JM, Blake AD, Zhang BB, Wilkinson HA. Strowski MZ, et al. Among authors: blake ad. Mol Endocrinol. 2003 Jan;17(1):93-106. doi: 10.1210/me.2001-0035. Mol Endocrinol. 2003. PMID: 12511609

8

Solid-phase synthesis, characterization and RNAi activity of branch and hyperbranch siRNAs.

Maina A, Blackman BA, Parronchi CJ, Morozko E, Bender ME, Blake AD, Sabatino D. Maina A, et al. Among authors: blake ad. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5270-4. doi: 10.1016/j.bmcl.2013.08.033. Epub 2013 Aug 12. Bioorg Med Chem Lett. 2013. PMID: 23988358

9

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

Strader CD, Dixon RA, Cheung AH, Candelore MR, Blake AD, Sigal IS. Strader CD, et al. Among authors: blake ad. J Biol Chem. 1987 Dec 5;262(34):16439-43. J Biol Chem. 1987. PMID: 2890637 Free article.

A. F., Sigal, I. S., Rands, E., Register, R. B., Candelore, M. R., Blake, A. D., and Strader, C. D. (1987) Nature 326, 73-77). This mutant receptor (D(239-272)beta AR) bound the agonist isoproterenol with a single class of binding sites, in contrast to …

A. F., Sigal, I. S., Rands, E., Register, R. B., Candelore, M. R., Blake, A. D., and Strader, C. D. (1987) Nature 326, …

10

The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states.

Di Salvo J, Koch GE, Johnson KE, Blake AD, Daugherty BL, DeMartino JA, Sirotina-Meisher A, Liu Y, Springer MS, Cascieri MA, Sullivan KA. Di Salvo J, et al. Among authors: blake ad. Eur J Pharmacol. 2000 Dec 8;409(2):143-54. doi: 10.1016/s0014-2999(00)00846-3. Eur J Pharmacol. 2000. PMID: 11104827

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