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Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits.
Reyes-Ortiz AM, Abud EM, Burns MS, Wu J, Hernandez SJ, McClure N, Wang KQ, Schulz CJ, Miramontes R, Lau A, Michael N, Miyoshi E, Van Vactor D, Reidling JC, Blurton-Jones M, Swarup V, Poon WW, Lim RG, Thompson LM. Reyes-Ortiz AM, et al. iScience. 2022 Dec 6;26(1):105732. doi: 10.1016/j.isci.2022.105732. eCollection 2023 Jan 20. iScience. 2022. PMID: 36590162 Free PMC article.
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. Rodriguez-Ortiz CJ, et al. Am J Pathol. 2013 Aug;183(2):504-15. doi: 10.1016/j.ajpath.2013.04.014. Epub 2013 Jun 5. Am J Pathol. 2013. PMID: 23747512 Free PMC article.
Inflammatory changes parallel the early stages of Alzheimer disease.
Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. Parachikova A, et al. Neurobiol Aging. 2007 Dec;28(12):1821-33. doi: 10.1016/j.neurobiolaging.2006.08.014. Epub 2006 Oct 18. Neurobiol Aging. 2007. PMID: 17052803 Free PMC article.
94 results