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In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine.
Ballet V, Bohme GA, Brohan E, Boukaiba R, Chambard JM, Angouillant-Boniface O, Carriot T, Chantoiseau C, Fouconnier S, Houtmann S, Prévost C, Schombert B, Schio L, Partiseti M. Ballet V, et al. Among authors: bohme ga. Eur J Pharmacol. 2022 Jan 15;915:174670. doi: 10.1016/j.ejphar.2021.174670. Epub 2021 Dec 2. Eur J Pharmacol. 2022. PMID: 34863995 Free PMC article.
The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels.
Sanson C, Boukaiba R, Houtmann S, Maizières MA, Fouconnier S, Partiseti M, Bohme GA. Sanson C, et al. Among authors: bohme ga. Naunyn Schmiedebergs Arch Pharmacol. 2022 Jun;395(6):735-740. doi: 10.1007/s00210-022-02240-4. Epub 2022 Apr 12. Naunyn Schmiedebergs Arch Pharmacol. 2022. PMID: 35412073
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Kramer J, Himmel HM, Lindqvist A, Stoelzle-Feix S, Chaudhary KW, Li D, Bohme GA, Bridgland-Taylor M, Hebeisen S, Fan J, Renganathan M, Imredy J, Humphries ESA, Brinkwirth N, Strassmaier T, Ohtsuki A, Danker T, Vanoye C, Polonchuk L, Fermini B, Pierson JB, Gintant G. Kramer J, et al. Among authors: bohme ga. Sci Rep. 2020 Mar 27;10(1):5627. doi: 10.1038/s41598-020-62344-w. Sci Rep. 2020. PMID: 32221320 Free PMC article.
Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Kramer J, Himmel HM, Lindqvist A, Stoelzle-Feix S, Chaudhary KW, Li D, Bohme GA, Bridgland-Taylor M, Hebeisen S, Fan J, Renganathan M, Imredy J, Humphries ESA, Brinkwirth N, Strassmaier T, Ohtsuki A, Danker T, Vanoye C, Polonchuk L, Fermini B, Pierson JB, Gintant G. Kramer J, et al. Among authors: bohme ga. Sci Rep. 2020 Jul 14;10(1):11884. doi: 10.1038/s41598-020-68819-0. Sci Rep. 2020. PMID: 32665705 Free PMC article.
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
Jimonet P, Bohme GA, Bouquerel J, Boireau A, Damour D, Debono MW, Genevois-Borella A, Hardy JC, Hubert P, Manfré F, Nemecek P, Pratt J, Randle JC, Ribeill Y, Stutzmann JM, Vuilhorgne M, Mignani S. Jimonet P, et al. Among authors: bohme ga. Bioorg Med Chem Lett. 2001 Jan 22;11(2):127-32. doi: 10.1016/s0960-894x(00)00592-8. Bioorg Med Chem Lett. 2001. PMID: 11206442
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
Stutzmann JM, Bohme GA, Boireau A, Damour D, Debono MW, Genevois-Borella A, Jimonet P, Pratt J, Randle JC, Ribeill Y, Vuilhorgne M, Mignani S. Stutzmann JM, et al. Among authors: bohme ga. Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10. doi: 10.1016/s0960-894x(01)00180-9. Bioorg Med Chem Lett. 2001. PMID: 11354378
RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.
Canton T, Böhme GA, Boireau A, Bordier F, Mignani S, Jimonet P, Jahn G, Alavijeh M, Stygall J, Roberts S, Brealey C, Vuilhorgne M, Debono MW, Le Guern S, Laville M, Briet D, Roux M, Stutzmann JM, Pratt J. Canton T, et al. Among authors: bohme ga. J Pharmacol Exp Ther. 2001 Oct;299(1):314-22. J Pharmacol Exp Ther. 2001. PMID: 11561094
61 results