Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts.
Güttinger M, Padrun V, Pralong WF, Boison D.
Güttinger M, et al. Among authors: boison d.
Exp Neurol. 2005 May;193(1):53-64. doi: 10.1016/j.expneurol.2004.12.012.
Exp Neurol. 2005.
PMID: 15817264
In a previous ex vivo gene therapy approach, local release of adenosine by encapsulated fibroblasts implanted into the vicinity of an epileptic focus, was sufficient to provide transient protection from seizures (Huber, A., Padrun, V., Deglon, N., Aebischer, P., Mohler, H., Bo …
In a previous ex vivo gene therapy approach, local release of adenosine by encapsulated fibroblasts implanted into the vicinity of an epilep …