Bolhuis RL - Search Results

1

Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity.

Weijtens ME, Willemsen RA, Valerio D, Stam K, Bolhuis RL. Weijtens ME, et al. Among authors: bolhuis rl. J Immunol. 1996 Jul 15;157(2):836-43. J Immunol. 1996. PMID: 8752936

2

Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes.

Schaft N, Willemsen RA, de Vries J, Lankiewicz B, Essers BW, Gratama JW, Figdor CG, Bolhuis RL, Debets R, Adema GJ. Schaft N, et al. Among authors: bolhuis rl. J Immunol. 2003 Feb 15;170(4):2186-94. doi: 10.4049/jimmunol.170.4.2186. J Immunol. 2003. PMID: 12574392

3

Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules.

Weijtens ME, Willemsen RA, van Krimpen BA, Bolhuis RL. Weijtens ME, et al. Among authors: bolhuis rl. Int J Cancer. 1998 Jul 17;77(2):181-7. doi: 10.1002/(sici)1097-0215(19980717)77:2<181::aid-ijc2>3.0.co;2-m. Int J Cancer. 1998. PMID: 9650549 Free article.

4

A retroviral vector system 'STITCH' in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes.

Weijtens ME, Willemsen RA, Hart EH, Bolhuis RL. Weijtens ME, et al. Among authors: bolhuis rl. Gene Ther. 1998 Sep;5(9):1195-203. doi: 10.1038/sj.gt.3300696. Gene Ther. 1998. PMID: 9930320

5

Preparation for a phase I/II study using autologous gene modified T lymphocytes for treatment of metastatic renal cancer patients.

Bolhuis RL, Willemsen RA, Lamers CH, Stam K, Gratama JW, Weijtens ME. Bolhuis RL, et al. Adv Exp Med Biol. 1998;451:547-55. doi: 10.1007/978-1-4615-5357-1_85. Adv Exp Med Biol. 1998. PMID: 10026926 Clinical Trial. No abstract available.

6

Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production.

Weijtens ME, Hart EH, Bolhuis RL. Weijtens ME, et al. Among authors: bolhuis rl. Gene Ther. 2000 Jan;7(1):35-42. doi: 10.1038/sj.gt.3301051. Gene Ther. 2000. PMID: 10680014

7

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

Willemsen RA, Weijtens ME, Ronteltap C, Eshhar Z, Gratama JW, Chames P, Bolhuis RL. Willemsen RA, et al. Among authors: bolhuis rl. Gene Ther. 2000 Aug;7(16):1369-77. doi: 10.1038/sj.gt.3301253. Gene Ther. 2000. PMID: 10981663

8

Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha.

Willemsen R, Ronteltap C, Heuveling M, Debets R, Bolhuis R. Willemsen R, et al. Gene Ther. 2005 Jan;12(2):140-6. doi: 10.1038/sj.gt.3302388. Gene Ther. 2005. PMID: 15496961

9

T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production.

Schaft N, Lankiewicz B, Drexhage J, Berrevoets C, Moss DJ, Levitsky V, Bonneville M, Lee SP, McMichael AJ, Gratama JW, Bolhuis RL, Willemsen R, Debets R. Schaft N, et al. Among authors: bolhuis rl. Int Immunol. 2006 Apr;18(4):591-601. doi: 10.1093/intimm/dxh401. Epub 2006 Feb 28. Int Immunol. 2006. PMID: 16507598

10

Genetic correction of cultured T cells from an adenosine deaminase-deficient patient: characteristics of non-transduced and transduced T cells.

Braakman E, Van Beusechem VW, Van Krimpen BA, Fischer A, Bolhuis RL, Valerio D. Braakman E, et al. Among authors: bolhuis rl. Eur J Immunol. 1992 Jan;22(1):63-9. doi: 10.1002/eji.1830220111. Eur J Immunol. 1992. PMID: 1730260

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