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MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Büttner R, Ullrich RT, Siveke JT, Ohashi K, Schlee M, Sos ML. Brägelmann J, et al. Among authors: borchmann s. Nat Commun. 2021 Sep 17;12(1):5505. doi: 10.1038/s41467-021-25728-8. Nat Commun. 2021. PMID: 34535668 Free PMC article.
The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma.
Rothe A, Jachimowicz RD, Borchmann S, Madlener M, Keßler J, Reiners KS, Sauer M, Hansen HP, Ullrich RT, Chatterjee S, Borchmann P, Yazaki P, Koslowsky TC, Engert A, Heukamp LC, Hallek M, von Strandmann EP. Rothe A, et al. Among authors: borchmann s, borchmann p. Int J Cancer. 2014 Jun 15;134(12):2829-40. doi: 10.1002/ijc.28609. Epub 2013 Nov 29. Int J Cancer. 2014. PMID: 24242212 Free article.
Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer.
Meder L, Schuldt P, Thelen M, Schmitt A, Dietlein F, Klein S, Borchmann S, Wennhold K, Vlasic I, Oberbeck S, Riedel R, Florin A, Golfmann K, Schlößer HA, Odenthal M, Buettner R, Wolf J, Hallek M, Herling M, von Bergwelt-Baildon M, Reinhardt HC, Ullrich RT. Meder L, et al. Among authors: borchmann s. Cancer Res. 2018 Aug 1;78(15):4270-4281. doi: 10.1158/0008-5472.CAN-17-2176. Epub 2018 May 18. Cancer Res. 2018. PMID: 29776963
Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC.
Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, Dietlein F, Borchmann S, Chatterjee S, Siobal M, Schöttle J, Florin A, Koker M, Nill M, Ozretić L, Uhlenbrock N, Smith S, Büttner R, Miao H, Wang B, Reinhardt HC, Rauh D, Hallek M, Acker-Palmer A, Heukamp LC, Ullrich RT. Volz C, et al. Among authors: borchmann s. Cell Rep. 2020 Apr 28;31(4):107568. doi: 10.1016/j.celrep.2020.107568. Cell Rep. 2020. PMID: 32348765 Free article.
Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors.
Borchmann S, Selenz C, Lohmann M, Ludwig H, Gassa A, Brägelmann J, Lohneis P, Meder L, Mattlener J, Breid S, Nill M, Fassunke J, Wisdom AJ, Compes A, Gathof B, Alakus H, Kirsch D, Hekmat K, Büttner R, Reinhardt HC, Hallek M, Ullrich RT. Borchmann S, et al. J Immunother Cancer. 2022 Oct;10(10):e004781. doi: 10.1136/jitc-2022-004781. J Immunother Cancer. 2022. PMID: 36223955 Free PMC article.
In-depth cell-free DNA sequencing reveals genomic landscape of Hodgkin's lymphoma and facilitates ultrasensitive residual disease detection.
Sobesky S, Mammadova L, Cirillo M, Drees EEE, Mattlener J, Dörr H, Altmüller J, Shi Z, Bröckelmann PJ, Weiss J, Kreissl S, Sasse S, Ullrich RT, Reinke S, Klapper W, Gerhard-Hartmann E, Rosenwald A, Roemer MGM, Nürnberg P, Hagenbeek A, Zijlstra JM, Pegtel DM, Engert A, Borchmann P, von Tresckow B, Borchmann S. Sobesky S, et al. Among authors: borchmann s. Med. 2021 Oct 8;2(10):1171-1193.e11. doi: 10.1016/j.medj.2021.09.002. Med. 2021. PMID: 35590205 Free article.
The translational science of hodgkin lymphoma.
Cirillo M, Reinke S, Klapper W, Borchmann S. Cirillo M, et al. Among authors: borchmann s. Br J Haematol. 2019 Jan;184(1):30-44. doi: 10.1111/bjh.15658. Epub 2018 Nov 12. Br J Haematol. 2019. PMID: 30417946 Free article. Review.
47 results