Botas J - Search Results

1

RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.

Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JSC, Orr HT, Westbrook TF, Botas J, Zoghbi HY. Park J, et al. Among authors: botas j. Nature. 2013 Jun 20;498(7454):325-331. doi: 10.1038/nature12204. Epub 2013 May 29. Nature. 2013. PMID: 23719381 Free PMC article.

2

Identification of genes that modify ataxin-1-induced neurodegeneration.

Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, She WC, Luchak JM, Martinez P, Turiegano E, Benito J, Capovilla M, Skinner PJ, McCall A, Canal I, Orr HT, Zoghbi HY, Botas J. Fernandez-Funez P, et al. Among authors: botas j. Nature. 2000 Nov 2;408(6808):101-6. doi: 10.1038/35040584. Nature. 2000. PMID: 11081516

3

Mouse and fly models of neurodegeneration.

Zoghbi HY, Botas J. Zoghbi HY, et al. Among authors: botas j. Trends Genet. 2002 Sep;18(9):463-71. doi: 10.1016/s0168-9525(02)02729-4. Trends Genet. 2002. PMID: 12175807 Review.

4

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY. Chen HK, et al. Among authors: botas j. Cell. 2003 May 16;113(4):457-68. doi: 10.1016/s0092-8674(03)00349-0. Cell. 2003. PMID: 12757707 Free article.

5

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.

Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. Tsuda H, et al. Among authors: botas j. Cell. 2005 Aug 26;122(4):633-44. doi: 10.1016/j.cell.2005.06.012. Cell. 2005. PMID: 16122429 Free article.

6

MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1.

de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Faustino NA, Ashizawa T, Cooper TA, Botas J. de Haro M, et al. Among authors: botas j. Hum Mol Genet. 2006 Jul 1;15(13):2138-45. doi: 10.1093/hmg/ddl137. Epub 2006 May 24. Hum Mol Genet. 2006. PMID: 16723374

7

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: botas j. J Biol Chem. 2006 Sep 8;281(36):26714-24. doi: 10.1074/jbc.M601603200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831871 Free article.

8

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.

Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY. Lam YC, et al. Among authors: botas j. Cell. 2006 Dec 29;127(7):1335-47. doi: 10.1016/j.cell.2006.11.038. Cell. 2006. PMID: 17190598 Free article.

9

Drosophila researchers focus on human disease.

Botas J. Botas J. Nat Genet. 2007 May;39(5):589-91. doi: 10.1038/ng0507-589. Nat Genet. 2007. PMID: 17460691 No abstract available.

10

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J. Branco J, et al. Among authors: botas j. Hum Mol Genet. 2008 Feb 1;17(3):376-90. doi: 10.1093/hmg/ddm315. Epub 2007 Nov 5. Hum Mol Genet. 2008. PMID: 17984172

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